Therapeutic Potential of Chinese Herbal Medicines in Alcoholic Liver Disease
Alcoholic liver disease (ALD) is a complex chronic disease and is associated with a spectrum of liver injury ranging from steatosis and steatohepatitis to fibrosis and cirrhosis. Since effective therapies for ALD are still limited, Chinese herbal medicine is thought to be an important and alternativ...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2012-04-01
|
| Series: | Journal of Traditional and Complementary Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2225411016300840 |
| _version_ | 1818886793119924224 |
|---|---|
| author | Kuan-Hung Lu Chun-Ting Liu Rajasekaran Raghu Lee-Yan Sheen |
| author_facet | Kuan-Hung Lu Chun-Ting Liu Rajasekaran Raghu Lee-Yan Sheen |
| author_sort | Kuan-Hung Lu |
| collection | DOAJ |
| description | Alcoholic liver disease (ALD) is a complex chronic disease and is associated with a spectrum of liver injury ranging from steatosis and steatohepatitis to fibrosis and cirrhosis. Since effective therapies for ALD are still limited, Chinese herbal medicine is thought to be an important and alternative approach. This review focuses on the current scientific evidence of ALD by ten Chinese Materia Medica (中藥 zhōng yào), including Salviae Miltiorrhizae Radix (丹參 dān shēn), Notoginseng Radix (三七 sān qī), Lycii Fructus (枸杞子 gǒu qǐ zǐ), Cnidii Fructus (蛇床子 shé chuáng zǐ), Gentianae Radix (龍膽 lóng dǎn), Puerariae Radix (葛根 gé gēn), Puerariae Flos (葛花 gé huā), Magnoliae Officinalis Cortex (厚朴 hòu pò), Platycodonis Radix (桔梗 jié gěng), and Trigonellae Semen (胡蘆巴 hú lú bā). Potential mechanisms of these herbal medicines in ALD are involved in amelioration of enhanced inflammation, reduction of hepatic oxidative stress and lipogenesis, and enhancement of intestinal permeability in alcohol-induced liver injury models in vitro and in vivo. Accordingly, the evidenced therapeutic potential suggests that these herbs are promising candidates for prevention and development of new drugs for ALD in the future. |
| first_indexed | 2024-12-19T16:26:59Z |
| format | Article |
| id | doaj.art-9ad90d068ca84d589a230702b02f8a30 |
| institution | Directory Open Access Journal |
| issn | 2225-4110 |
| language | English |
| last_indexed | 2024-12-19T16:26:59Z |
| publishDate | 2012-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional and Complementary Medicine |
| spelling | doaj.art-9ad90d068ca84d589a230702b02f8a302022-12-21T20:14:19ZengElsevierJournal of Traditional and Complementary Medicine2225-41102012-04-012211512210.1016/S2225-4110(16)30084-0Therapeutic Potential of Chinese Herbal Medicines in Alcoholic Liver DiseaseKuan-Hung LuChun-Ting LiuRajasekaran RaghuLee-Yan SheenAlcoholic liver disease (ALD) is a complex chronic disease and is associated with a spectrum of liver injury ranging from steatosis and steatohepatitis to fibrosis and cirrhosis. Since effective therapies for ALD are still limited, Chinese herbal medicine is thought to be an important and alternative approach. This review focuses on the current scientific evidence of ALD by ten Chinese Materia Medica (中藥 zhōng yào), including Salviae Miltiorrhizae Radix (丹參 dān shēn), Notoginseng Radix (三七 sān qī), Lycii Fructus (枸杞子 gǒu qǐ zǐ), Cnidii Fructus (蛇床子 shé chuáng zǐ), Gentianae Radix (龍膽 lóng dǎn), Puerariae Radix (葛根 gé gēn), Puerariae Flos (葛花 gé huā), Magnoliae Officinalis Cortex (厚朴 hòu pò), Platycodonis Radix (桔梗 jié gěng), and Trigonellae Semen (胡蘆巴 hú lú bā). Potential mechanisms of these herbal medicines in ALD are involved in amelioration of enhanced inflammation, reduction of hepatic oxidative stress and lipogenesis, and enhancement of intestinal permeability in alcohol-induced liver injury models in vitro and in vivo. Accordingly, the evidenced therapeutic potential suggests that these herbs are promising candidates for prevention and development of new drugs for ALD in the future.http://www.sciencedirect.com/science/article/pii/S2225411016300840Alcoholic liver diseaseAlcohol-induced liver injuryHerbal medicineChinese Materia MedicaTraditional Chinese medicine |
| spellingShingle | Kuan-Hung Lu Chun-Ting Liu Rajasekaran Raghu Lee-Yan Sheen Therapeutic Potential of Chinese Herbal Medicines in Alcoholic Liver Disease Journal of Traditional and Complementary Medicine Alcoholic liver disease Alcohol-induced liver injury Herbal medicine Chinese Materia Medica Traditional Chinese medicine |
| title | Therapeutic Potential of Chinese Herbal Medicines in Alcoholic Liver Disease |
| title_full | Therapeutic Potential of Chinese Herbal Medicines in Alcoholic Liver Disease |
| title_fullStr | Therapeutic Potential of Chinese Herbal Medicines in Alcoholic Liver Disease |
| title_full_unstemmed | Therapeutic Potential of Chinese Herbal Medicines in Alcoholic Liver Disease |
| title_short | Therapeutic Potential of Chinese Herbal Medicines in Alcoholic Liver Disease |
| title_sort | therapeutic potential of chinese herbal medicines in alcoholic liver disease |
| topic | Alcoholic liver disease Alcohol-induced liver injury Herbal medicine Chinese Materia Medica Traditional Chinese medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2225411016300840 |
| work_keys_str_mv | AT kuanhunglu therapeuticpotentialofchineseherbalmedicinesinalcoholicliverdisease AT chuntingliu therapeuticpotentialofchineseherbalmedicinesinalcoholicliverdisease AT rajasekaranraghu therapeuticpotentialofchineseherbalmedicinesinalcoholicliverdisease AT leeyansheen therapeuticpotentialofchineseherbalmedicinesinalcoholicliverdisease |