The relationship between serum klotho and cognitive performance in a nationally representative sample of US adults
PurposeAging is the primary risk factor for cognitive decline. Serum klotho, as an anti-aging protein, may be involved in cognitive decline. Thus, we aim to explorer the correlation between serum klotho and cognitive performance among an older adult population in the United States.MethodsWe performe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1053390/full |
| _version_ | 1797935476232945664 |
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| author | Deng Linghui Yu Simin Zhang Zilong Li Yuxiao Qiu Shi Dong Birong |
| author_facet | Deng Linghui Yu Simin Zhang Zilong Li Yuxiao Qiu Shi Dong Birong |
| author_sort | Deng Linghui |
| collection | DOAJ |
| description | PurposeAging is the primary risk factor for cognitive decline. Serum klotho, as an anti-aging protein, may be involved in cognitive decline. Thus, we aim to explorer the correlation between serum klotho and cognitive performance among an older adult population in the United States.MethodsWe performed a cross-sectional study using data from NHANES 2011–2014. Serum klotho was analyzed by ELISA. Cognitive function was measured by Establish a Registry for Alzheimer’s Disease (CERAD) test, Animal Fluency test and Digit Symbol Substitution Test (DSST) score. The relationship between serum klotho and cognition was analyzed by a multivariable regression model.ResultsA total of 2,171 participants aged 60–79 years were included. Median serum klotho concentration was 851.52 pg./ml (SD = 294.07). We also categorized serum klotho concentrates into quartiles. After fully adjusting pertinent variables, compared to those with lowest klotho levels (206.3–658.4 pg./ml), individuals with highest klotho concentrates (983.3–3,456 pg./ml) had a higher CERAD score [β (95%CI): 0.97 (0.25, 1.69) p = 0.008] and DSST score [β (95%CI): 1.86 (0.25, 3.47), p = 0.024].ConclusionOur findings indicated that, among the general population of American older adults, serum klotho concentrates may serve as a marker of cognitive health. The benefits of klotho on aging process and neurodegenerative disorders should be paid more attention. |
| first_indexed | 2024-04-10T18:14:58Z |
| format | Article |
| id | doaj.art-9adb010c3d1941b98271851687710c99 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-10T18:14:58Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-9adb010c3d1941b98271851687710c992023-02-02T09:09:42ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-02-011510.3389/fnagi.2023.10533901053390The relationship between serum klotho and cognitive performance in a nationally representative sample of US adultsDeng Linghui0Yu Simin1Zhang Zilong2Li Yuxiao3Qiu Shi4Dong Birong5National Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, ChinaNational Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, ChinaNational Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaPurposeAging is the primary risk factor for cognitive decline. Serum klotho, as an anti-aging protein, may be involved in cognitive decline. Thus, we aim to explorer the correlation between serum klotho and cognitive performance among an older adult population in the United States.MethodsWe performed a cross-sectional study using data from NHANES 2011–2014. Serum klotho was analyzed by ELISA. Cognitive function was measured by Establish a Registry for Alzheimer’s Disease (CERAD) test, Animal Fluency test and Digit Symbol Substitution Test (DSST) score. The relationship between serum klotho and cognition was analyzed by a multivariable regression model.ResultsA total of 2,171 participants aged 60–79 years were included. Median serum klotho concentration was 851.52 pg./ml (SD = 294.07). We also categorized serum klotho concentrates into quartiles. After fully adjusting pertinent variables, compared to those with lowest klotho levels (206.3–658.4 pg./ml), individuals with highest klotho concentrates (983.3–3,456 pg./ml) had a higher CERAD score [β (95%CI): 0.97 (0.25, 1.69) p = 0.008] and DSST score [β (95%CI): 1.86 (0.25, 3.47), p = 0.024].ConclusionOur findings indicated that, among the general population of American older adults, serum klotho concentrates may serve as a marker of cognitive health. The benefits of klotho on aging process and neurodegenerative disorders should be paid more attention.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1053390/fullcognitive performanceklothoagingNHANESolder adults |
| spellingShingle | Deng Linghui Yu Simin Zhang Zilong Li Yuxiao Qiu Shi Dong Birong The relationship between serum klotho and cognitive performance in a nationally representative sample of US adults Frontiers in Aging Neuroscience cognitive performance klotho aging NHANES older adults |
| title | The relationship between serum klotho and cognitive performance in a nationally representative sample of US adults |
| title_full | The relationship between serum klotho and cognitive performance in a nationally representative sample of US adults |
| title_fullStr | The relationship between serum klotho and cognitive performance in a nationally representative sample of US adults |
| title_full_unstemmed | The relationship between serum klotho and cognitive performance in a nationally representative sample of US adults |
| title_short | The relationship between serum klotho and cognitive performance in a nationally representative sample of US adults |
| title_sort | relationship between serum klotho and cognitive performance in a nationally representative sample of us adults |
| topic | cognitive performance klotho aging NHANES older adults |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1053390/full |
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