Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain
Cadmium (Cd) is a well-known heavy metal and environmental toxicant and pollutant worldwide, being largely present in every kind of item such as plastic (toys), battery, paints, ceramics, contaminated water, air, soil, food, fertilizers, and cigarette smoke. Nowadays, it represents an important rese...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2020.604377/full |
| _version_ | 1819072671549227008 |
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| author | Jacopo Junio Valerio Branca Alessandra Pacini Massimo Gulisano Niccolò Taddei Claudia Fiorillo Matteo Becatti |
| author_facet | Jacopo Junio Valerio Branca Alessandra Pacini Massimo Gulisano Niccolò Taddei Claudia Fiorillo Matteo Becatti |
| author_sort | Jacopo Junio Valerio Branca |
| collection | DOAJ |
| description | Cadmium (Cd) is a well-known heavy metal and environmental toxicant and pollutant worldwide, being largely present in every kind of item such as plastic (toys), battery, paints, ceramics, contaminated water, air, soil, food, fertilizers, and cigarette smoke. Nowadays, it represents an important research area for the scientific community mainly for its effects on public health. Due to a half-life ranging between 15 and 30 years, Cd owns the ability to accumulate in organs and tissues, exerting deleterious effects. Thus, even at low doses, a Cd prolonged exposure may cause a multiorgan toxicity. Mitochondria are key intracellular targets for Cd-induced cytotoxicity, but the underlying mechanisms are not fully elucidated. The present review is aimed to clarify the effects of Cd on mitochondria and, particularly, on the mitochondrial electron transport chain. |
| first_indexed | 2024-12-21T17:41:26Z |
| format | Article |
| id | doaj.art-9ade34c785d747d98f7a80d756572382 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-21T17:41:26Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-9ade34c785d747d98f7a80d7565723822022-12-21T18:55:37ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-11-01810.3389/fcell.2020.604377604377Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport ChainJacopo Junio Valerio Branca0Alessandra Pacini1Massimo Gulisano2Niccolò Taddei3Claudia Fiorillo4Matteo Becatti5Department of Experimental and Clinical Medicine, Anatomy and Histology Section, University of Firenze, Firenze, ItalyDepartment of Experimental and Clinical Medicine, Anatomy and Histology Section, University of Firenze, Firenze, ItalyDepartment of Experimental and Clinical Medicine, Anatomy and Histology Section, University of Firenze, Firenze, ItalyDepartment of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Firenze, Firenze, ItalyDepartment of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Firenze, Firenze, ItalyDepartment of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Firenze, Firenze, ItalyCadmium (Cd) is a well-known heavy metal and environmental toxicant and pollutant worldwide, being largely present in every kind of item such as plastic (toys), battery, paints, ceramics, contaminated water, air, soil, food, fertilizers, and cigarette smoke. Nowadays, it represents an important research area for the scientific community mainly for its effects on public health. Due to a half-life ranging between 15 and 30 years, Cd owns the ability to accumulate in organs and tissues, exerting deleterious effects. Thus, even at low doses, a Cd prolonged exposure may cause a multiorgan toxicity. Mitochondria are key intracellular targets for Cd-induced cytotoxicity, but the underlying mechanisms are not fully elucidated. The present review is aimed to clarify the effects of Cd on mitochondria and, particularly, on the mitochondrial electron transport chain.https://www.frontiersin.org/articles/10.3389/fcell.2020.604377/fullcadmiumcytotoxicitymitochondriamitochondrial electron transport chainmitochondrial complexes |
| spellingShingle | Jacopo Junio Valerio Branca Alessandra Pacini Massimo Gulisano Niccolò Taddei Claudia Fiorillo Matteo Becatti Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain Frontiers in Cell and Developmental Biology cadmium cytotoxicity mitochondria mitochondrial electron transport chain mitochondrial complexes |
| title | Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain |
| title_full | Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain |
| title_fullStr | Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain |
| title_full_unstemmed | Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain |
| title_short | Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain |
| title_sort | cadmium induced cytotoxicity effects on mitochondrial electron transport chain |
| topic | cadmium cytotoxicity mitochondria mitochondrial electron transport chain mitochondrial complexes |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2020.604377/full |
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