Skeletal Muscle Fatigue in Slow and Fast Muscles of Type 2 Diabetic Sprague Dawley Rats
Background: To evaluate the effects of type 2 diabetes mellitus on fatigability of soleus (slow) and extensor digitorium longus (EDL) (fast) muscles of female Sprague Dawley rats. Methods:Twenty healthy female Sprague Dawley rats were divided into 2 groups with 10 rats each. Group I (control) was...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Rawalpindi Medical University
2017-12-01
|
| Series: | Journal of Rawalpindi Medical College |
| Subjects: | |
| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/817 |
| _version_ | 1811295487242797056 |
|---|---|
| author | Mehvish Ashfaq |
| author_facet | Mehvish Ashfaq |
| author_sort | Mehvish Ashfaq |
| collection | DOAJ |
| description | Background: To evaluate the effects of type 2 diabetes mellitus on fatigability of soleus (slow) and extensor digitorium longus (EDL) (fast) muscles of female Sprague Dawley rats.
Methods:Twenty healthy female Sprague Dawley rats were divided into 2 groups with 10 rats each. Group I (control) was fed with normal diet and group II (diabetic) was given high fat diet. Group II was given intra-peritoneal streptozotocin(STZ) (35mg/kg body weight) on 15th day. Body weight, blood glucose and TG:HDL ratio were estimated on 21st day to confirm type 2 diabetes mellitus (T2DM) induction. Soleus and extensor digitorium longus (EDL) muscles were removed intact and fixed in organ bath system containing Krebs-Ringer buffer solution and connected to data acquisition unit (iWorx®) to study their contractile and fatigability parameters.
Results: Soleus and extensor digotorium longus muscles of female diabetic rats displayed significantly (p<0.05) increased fatigability.
Conclusions:Fatigability of slow (soleus) and fast (EDL) muscles increases in T2DM.There occurs reduction in resistance to and recovery from fatigue in both slow and fast skeletal muscles of type 2 diabetic female Sprague Dawley rats |
| first_indexed | 2024-04-13T05:34:08Z |
| format | Article |
| id | doaj.art-9adf63b6bd764ed6a2de59d03be2c086 |
| institution | Directory Open Access Journal |
| issn | 1683-3562 1683-3570 |
| language | English |
| last_indexed | 2024-04-13T05:34:08Z |
| publishDate | 2017-12-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj.art-9adf63b6bd764ed6a2de59d03be2c0862022-12-22T03:00:21ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702017-12-01214Skeletal Muscle Fatigue in Slow and Fast Muscles of Type 2 Diabetic Sprague Dawley RatsMehvish Ashfaq0Department of Physiology, HITEC-Institute of Medical Sciences,TaxilaCanttBackground: To evaluate the effects of type 2 diabetes mellitus on fatigability of soleus (slow) and extensor digitorium longus (EDL) (fast) muscles of female Sprague Dawley rats. Methods:Twenty healthy female Sprague Dawley rats were divided into 2 groups with 10 rats each. Group I (control) was fed with normal diet and group II (diabetic) was given high fat diet. Group II was given intra-peritoneal streptozotocin(STZ) (35mg/kg body weight) on 15th day. Body weight, blood glucose and TG:HDL ratio were estimated on 21st day to confirm type 2 diabetes mellitus (T2DM) induction. Soleus and extensor digitorium longus (EDL) muscles were removed intact and fixed in organ bath system containing Krebs-Ringer buffer solution and connected to data acquisition unit (iWorx®) to study their contractile and fatigability parameters. Results: Soleus and extensor digotorium longus muscles of female diabetic rats displayed significantly (p<0.05) increased fatigability. Conclusions:Fatigability of slow (soleus) and fast (EDL) muscles increases in T2DM.There occurs reduction in resistance to and recovery from fatigue in both slow and fast skeletal muscles of type 2 diabetic female Sprague Dawley ratshttps://www.journalrmc.com/index.php/JRMC/article/view/817Fast twitch muscleSlow twitch muscleMuscle fatigueType 2 diabetes mellitus |
| spellingShingle | Mehvish Ashfaq Skeletal Muscle Fatigue in Slow and Fast Muscles of Type 2 Diabetic Sprague Dawley Rats Journal of Rawalpindi Medical College Fast twitch muscle Slow twitch muscle Muscle fatigue Type 2 diabetes mellitus |
| title | Skeletal Muscle Fatigue in Slow and Fast Muscles of Type 2 Diabetic Sprague Dawley Rats |
| title_full | Skeletal Muscle Fatigue in Slow and Fast Muscles of Type 2 Diabetic Sprague Dawley Rats |
| title_fullStr | Skeletal Muscle Fatigue in Slow and Fast Muscles of Type 2 Diabetic Sprague Dawley Rats |
| title_full_unstemmed | Skeletal Muscle Fatigue in Slow and Fast Muscles of Type 2 Diabetic Sprague Dawley Rats |
| title_short | Skeletal Muscle Fatigue in Slow and Fast Muscles of Type 2 Diabetic Sprague Dawley Rats |
| title_sort | skeletal muscle fatigue in slow and fast muscles of type 2 diabetic sprague dawley rats |
| topic | Fast twitch muscle Slow twitch muscle Muscle fatigue Type 2 diabetes mellitus |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/817 |
| work_keys_str_mv | AT mehvishashfaq skeletalmusclefatigueinslowandfastmusclesoftype2diabeticspraguedawleyrats |