Diffusion spectrum imaging predicts hippocampal sclerosis in mesial temporal lobe epilepsy patients
Abstract Objectives Epileptic patients suffer from seizure recurrence after surgery due to the challenging localization. Improvement of the noninvasive imaging‐based approach for a better definition of the abnormalities would be helpful for a better outcome. Methods The quantitative anisotropy (QA)...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-03-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51503 |
| _version_ | 1818445929975382016 |
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| author | Zhen‐Ming Wang Peng‐Hu Wei Miao Zhang Chunxue Wu Yi Shan Fang‐Cheng Yeh Yongzhi Shan Jie Lu |
| author_facet | Zhen‐Ming Wang Peng‐Hu Wei Miao Zhang Chunxue Wu Yi Shan Fang‐Cheng Yeh Yongzhi Shan Jie Lu |
| author_sort | Zhen‐Ming Wang |
| collection | DOAJ |
| description | Abstract Objectives Epileptic patients suffer from seizure recurrence after surgery due to the challenging localization. Improvement of the noninvasive imaging‐based approach for a better definition of the abnormalities would be helpful for a better outcome. Methods The quantitative anisotropy (QA) of diffusion spectrum imaging (DSI) is a quantitative scalar of evaluating the water diffusivity. Herein, we investigated the association between neuronal diameters or density acquired in literature and QA of DSI as well as the seizure localization in temporal lobe epilepsy. Thirty healthy controls (HCs) and 30 patients with hippocampal sclerosis (HS) were retrospectively analyzed. QA values were calculated and interactively compared between the areas with different neuronal diameter/density acquired from literature in the HCP‐1021 template. Diagnostic tests were performed on Z‐transformed asymmetry indices (AIs) of QA (which exclude physical asymmetry) among HS patients to evaluate its clinical value. Results The QA values in HCs conformed with different pyramidal cell distributions ranged from giant to small; corresponding groups were the motor‐sensory, associative, and limbic groups, respectively. Additionally, the QA value was correlated with the neuronal diameter/density in cortical layer IIIc (correlation coefficient with diameter: 0.529, p = 0.035; density: −0.678, p = 0.011). Decreases in cingulum hippocampal segments (Chs) were consistently observed on the sclerosed side in patients. The area under the curve of the Z‐transformed AI in Chs to the lateralization of HS was 0.957 (sensitivity: 0.909, specificity: 0.895). Interpretation QA based on DSI is likely to be useful to provide information to reflect the neuronal diameter/density and further facilitate localization of epileptic tissues. |
| first_indexed | 2024-12-14T19:39:39Z |
| format | Article |
| id | doaj.art-9ae0be03cec44c3d8380c34065f0881a |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-12-14T19:39:39Z |
| publishDate | 2022-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-9ae0be03cec44c3d8380c34065f0881a2022-12-21T22:49:44ZengWileyAnnals of Clinical and Translational Neurology2328-95032022-03-019324225210.1002/acn3.51503Diffusion spectrum imaging predicts hippocampal sclerosis in mesial temporal lobe epilepsy patientsZhen‐Ming Wang0Peng‐Hu Wei1Miao Zhang2Chunxue Wu3Yi Shan4Fang‐Cheng Yeh5Yongzhi Shan6Jie Lu7Department of Radiology and Nuclear Medicine Xuanwu Hospital, Capital Medical University Beijing ChinaDepartment of Neurosurgery Xuanwu Hospital, Capital Medical University Beijing ChinaDepartment of Radiology and Nuclear Medicine Xuanwu Hospital, Capital Medical University Beijing ChinaDepartment of Radiology and Nuclear Medicine Xuanwu Hospital, Capital Medical University Beijing ChinaDepartment of Radiology and Nuclear Medicine Xuanwu Hospital, Capital Medical University Beijing ChinaDepartment of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USADepartment of Neurosurgery Xuanwu Hospital, Capital Medical University Beijing ChinaDepartment of Radiology and Nuclear Medicine Xuanwu Hospital, Capital Medical University Beijing ChinaAbstract Objectives Epileptic patients suffer from seizure recurrence after surgery due to the challenging localization. Improvement of the noninvasive imaging‐based approach for a better definition of the abnormalities would be helpful for a better outcome. Methods The quantitative anisotropy (QA) of diffusion spectrum imaging (DSI) is a quantitative scalar of evaluating the water diffusivity. Herein, we investigated the association between neuronal diameters or density acquired in literature and QA of DSI as well as the seizure localization in temporal lobe epilepsy. Thirty healthy controls (HCs) and 30 patients with hippocampal sclerosis (HS) were retrospectively analyzed. QA values were calculated and interactively compared between the areas with different neuronal diameter/density acquired from literature in the HCP‐1021 template. Diagnostic tests were performed on Z‐transformed asymmetry indices (AIs) of QA (which exclude physical asymmetry) among HS patients to evaluate its clinical value. Results The QA values in HCs conformed with different pyramidal cell distributions ranged from giant to small; corresponding groups were the motor‐sensory, associative, and limbic groups, respectively. Additionally, the QA value was correlated with the neuronal diameter/density in cortical layer IIIc (correlation coefficient with diameter: 0.529, p = 0.035; density: −0.678, p = 0.011). Decreases in cingulum hippocampal segments (Chs) were consistently observed on the sclerosed side in patients. The area under the curve of the Z‐transformed AI in Chs to the lateralization of HS was 0.957 (sensitivity: 0.909, specificity: 0.895). Interpretation QA based on DSI is likely to be useful to provide information to reflect the neuronal diameter/density and further facilitate localization of epileptic tissues.https://doi.org/10.1002/acn3.51503 |
| spellingShingle | Zhen‐Ming Wang Peng‐Hu Wei Miao Zhang Chunxue Wu Yi Shan Fang‐Cheng Yeh Yongzhi Shan Jie Lu Diffusion spectrum imaging predicts hippocampal sclerosis in mesial temporal lobe epilepsy patients Annals of Clinical and Translational Neurology |
| title | Diffusion spectrum imaging predicts hippocampal sclerosis in mesial temporal lobe epilepsy patients |
| title_full | Diffusion spectrum imaging predicts hippocampal sclerosis in mesial temporal lobe epilepsy patients |
| title_fullStr | Diffusion spectrum imaging predicts hippocampal sclerosis in mesial temporal lobe epilepsy patients |
| title_full_unstemmed | Diffusion spectrum imaging predicts hippocampal sclerosis in mesial temporal lobe epilepsy patients |
| title_short | Diffusion spectrum imaging predicts hippocampal sclerosis in mesial temporal lobe epilepsy patients |
| title_sort | diffusion spectrum imaging predicts hippocampal sclerosis in mesial temporal lobe epilepsy patients |
| url | https://doi.org/10.1002/acn3.51503 |
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