Oral direct renin inhibitor aliskiren reduces in vivo oxidative stress and serum matrix metalloproteinase-2 levels in patients with permanent atrial fibrillation
We aimed to determine the effects of the oral direct renin inhibitor aliskiren on in vivo oxidative stress in atrial fibrillation (AF) patients. In this study, 150 mg oral direct renin inhibitor aliskiren was administered once daily to 12 permanent AF patients. Aliskiren significantly reduced urinar...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-04-01
|
| Series: | Journal of Arrhythmia |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1880427614001252 |
| _version_ | 1818264945667604480 |
|---|---|
| author | Yoshizumi Takei, MD Minoru Ichikawa, MD, PhD Yoshiyuki Kijima, MD, PhD |
| author_facet | Yoshizumi Takei, MD Minoru Ichikawa, MD, PhD Yoshiyuki Kijima, MD, PhD |
| author_sort | Yoshizumi Takei, MD |
| collection | DOAJ |
| description | We aimed to determine the effects of the oral direct renin inhibitor aliskiren on in vivo oxidative stress in atrial fibrillation (AF) patients. In this study, 150 mg oral direct renin inhibitor aliskiren was administered once daily to 12 permanent AF patients. Aliskiren significantly reduced urinary excretion of the oxidative stress biomarker 8-iso-prostglandin F2α and serum levels of matrix metalloproteinase-2(MMP-2). We concluded that aliskiren reduces in vivo oxidative stress and serum MMP-2 levels in patients with permanent AF. |
| first_indexed | 2024-12-12T19:42:59Z |
| format | Article |
| id | doaj.art-9ae18346e7ca4c8aac8e7824e9a5eae8 |
| institution | Directory Open Access Journal |
| issn | 1880-4276 |
| language | English |
| last_indexed | 2024-12-12T19:42:59Z |
| publishDate | 2015-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Arrhythmia |
| spelling | doaj.art-9ae18346e7ca4c8aac8e7824e9a5eae82022-12-22T00:14:09ZengWileyJournal of Arrhythmia1880-42762015-04-01312767710.1016/j.joa.2014.07.002Oral direct renin inhibitor aliskiren reduces in vivo oxidative stress and serum matrix metalloproteinase-2 levels in patients with permanent atrial fibrillationYoshizumi Takei, MDMinoru Ichikawa, MD, PhDYoshiyuki Kijima, MD, PhDWe aimed to determine the effects of the oral direct renin inhibitor aliskiren on in vivo oxidative stress in atrial fibrillation (AF) patients. In this study, 150 mg oral direct renin inhibitor aliskiren was administered once daily to 12 permanent AF patients. Aliskiren significantly reduced urinary excretion of the oxidative stress biomarker 8-iso-prostglandin F2α and serum levels of matrix metalloproteinase-2(MMP-2). We concluded that aliskiren reduces in vivo oxidative stress and serum MMP-2 levels in patients with permanent AF.http://www.sciencedirect.com/science/article/pii/S1880427614001252Atrial fibrillationFree radicalsMatrix metalloproteinase |
| spellingShingle | Yoshizumi Takei, MD Minoru Ichikawa, MD, PhD Yoshiyuki Kijima, MD, PhD Oral direct renin inhibitor aliskiren reduces in vivo oxidative stress and serum matrix metalloproteinase-2 levels in patients with permanent atrial fibrillation Journal of Arrhythmia Atrial fibrillation Free radicals Matrix metalloproteinase |
| title | Oral direct renin inhibitor aliskiren reduces in vivo oxidative stress and serum matrix metalloproteinase-2 levels in patients with permanent atrial fibrillation |
| title_full | Oral direct renin inhibitor aliskiren reduces in vivo oxidative stress and serum matrix metalloproteinase-2 levels in patients with permanent atrial fibrillation |
| title_fullStr | Oral direct renin inhibitor aliskiren reduces in vivo oxidative stress and serum matrix metalloproteinase-2 levels in patients with permanent atrial fibrillation |
| title_full_unstemmed | Oral direct renin inhibitor aliskiren reduces in vivo oxidative stress and serum matrix metalloproteinase-2 levels in patients with permanent atrial fibrillation |
| title_short | Oral direct renin inhibitor aliskiren reduces in vivo oxidative stress and serum matrix metalloproteinase-2 levels in patients with permanent atrial fibrillation |
| title_sort | oral direct renin inhibitor aliskiren reduces in vivo oxidative stress and serum matrix metalloproteinase 2 levels in patients with permanent atrial fibrillation |
| topic | Atrial fibrillation Free radicals Matrix metalloproteinase |
| url | http://www.sciencedirect.com/science/article/pii/S1880427614001252 |
| work_keys_str_mv | AT yoshizumitakeimd oraldirectrenininhibitoraliskirenreducesinvivooxidativestressandserummatrixmetalloproteinase2levelsinpatientswithpermanentatrialfibrillation AT minoruichikawamdphd oraldirectrenininhibitoraliskirenreducesinvivooxidativestressandserummatrixmetalloproteinase2levelsinpatientswithpermanentatrialfibrillation AT yoshiyukikijimamdphd oraldirectrenininhibitoraliskirenreducesinvivooxidativestressandserummatrixmetalloproteinase2levelsinpatientswithpermanentatrialfibrillation |