Preliminary Study on Safety Assessment of 10 Hz Transcranial Alternating Current Stimulation in Rat Brain
Assessment of the safety of transcranial electrical stimulation devices that contact the scalp and apply electrical stimulations to brain tissues is essential for the prevention of unexpected brain damage caused by electromagnetic fields. In particular, safety studies on transcranial alternating cur...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/11/5299 |
| _version_ | 1797494333861003264 |
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| author | Sung Suk Oh Yoon Bum Lee Jae Sun Jeon Sang-Hyun An Jong-ryul Choi |
| author_facet | Sung Suk Oh Yoon Bum Lee Jae Sun Jeon Sang-Hyun An Jong-ryul Choi |
| author_sort | Sung Suk Oh |
| collection | DOAJ |
| description | Assessment of the safety of transcranial electrical stimulation devices that contact the scalp and apply electrical stimulations to brain tissues is essential for the prevention of unexpected brain damage caused by electromagnetic fields. In particular, safety studies on transcranial alternating current stimulation (tACS) are needed for active applications to treat brain diseases and for the development of medical devices, because there is a lack of research on the safety of tACS, in contrast to transcranial direct current stimulation. In this study, the safety of tACS with selected parameters, i.e., a stimulation intensity of 1.0 to 2.0 mA, a frequency of 10 Hz, and a treatment time of 20 min, was examined at a preclinical stage using small animals (rats). The results of magnetic resonance imaging and histopathological imaging indicated that the conditions applied in this study provided safe tACS without damaging brain tissues or neuronal components in the acute phase. In addition, the temperature did not increase above 41 °C, which is a temperature limitation for contact-type medical devices, even after 20 min of tACS application. |
| first_indexed | 2024-03-10T01:32:46Z |
| format | Article |
| id | doaj.art-9ae1ceaf0f044235a1cbecb1ed124392 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T01:32:46Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-9ae1ceaf0f044235a1cbecb1ed1243922023-11-23T13:39:19ZengMDPI AGApplied Sciences2076-34172022-05-011211529910.3390/app12115299Preliminary Study on Safety Assessment of 10 Hz Transcranial Alternating Current Stimulation in Rat BrainSung Suk Oh0Yoon Bum Lee1Jae Sun Jeon2Sang-Hyun An3Jong-ryul Choi4Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI Hub), Daegu 41061, KoreaPreclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI Hub), Daegu 41061, KoreaMedical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI Hub), Daegu 41061, KoreaPreclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI Hub), Daegu 41061, KoreaMedical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI Hub), Daegu 41061, KoreaAssessment of the safety of transcranial electrical stimulation devices that contact the scalp and apply electrical stimulations to brain tissues is essential for the prevention of unexpected brain damage caused by electromagnetic fields. In particular, safety studies on transcranial alternating current stimulation (tACS) are needed for active applications to treat brain diseases and for the development of medical devices, because there is a lack of research on the safety of tACS, in contrast to transcranial direct current stimulation. In this study, the safety of tACS with selected parameters, i.e., a stimulation intensity of 1.0 to 2.0 mA, a frequency of 10 Hz, and a treatment time of 20 min, was examined at a preclinical stage using small animals (rats). The results of magnetic resonance imaging and histopathological imaging indicated that the conditions applied in this study provided safe tACS without damaging brain tissues or neuronal components in the acute phase. In addition, the temperature did not increase above 41 °C, which is a temperature limitation for contact-type medical devices, even after 20 min of tACS application.https://www.mdpi.com/2076-3417/12/11/5299brain stimulationsafety assessmentmagnetic resonance imaginghistopathological analysistranscranial alternating current stimulationpreclinical study |
| spellingShingle | Sung Suk Oh Yoon Bum Lee Jae Sun Jeon Sang-Hyun An Jong-ryul Choi Preliminary Study on Safety Assessment of 10 Hz Transcranial Alternating Current Stimulation in Rat Brain Applied Sciences brain stimulation safety assessment magnetic resonance imaging histopathological analysis transcranial alternating current stimulation preclinical study |
| title | Preliminary Study on Safety Assessment of 10 Hz Transcranial Alternating Current Stimulation in Rat Brain |
| title_full | Preliminary Study on Safety Assessment of 10 Hz Transcranial Alternating Current Stimulation in Rat Brain |
| title_fullStr | Preliminary Study on Safety Assessment of 10 Hz Transcranial Alternating Current Stimulation in Rat Brain |
| title_full_unstemmed | Preliminary Study on Safety Assessment of 10 Hz Transcranial Alternating Current Stimulation in Rat Brain |
| title_short | Preliminary Study on Safety Assessment of 10 Hz Transcranial Alternating Current Stimulation in Rat Brain |
| title_sort | preliminary study on safety assessment of 10 hz transcranial alternating current stimulation in rat brain |
| topic | brain stimulation safety assessment magnetic resonance imaging histopathological analysis transcranial alternating current stimulation preclinical study |
| url | https://www.mdpi.com/2076-3417/12/11/5299 |
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