Generation of recombinant mAbs to vaccinia virus displaying high affinity and potent neutralization

Generation of recombinant mAbs to vaccinia virus displaying high affinity and potent neutralization

ABSTRACT Members of the Orthopoxvirus genus can cause severe infections in humans. Global vaccination against smallpox, caused by the variola virus, resulted in the eradication of the disease in 1980. Shortly thereafter, vaccination was discontinued, and as a result, a large proportion of the curren...

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Main Authors: Tal Noy-Porat, Hadas Tamir, Ron Alcalay, Ronit Rosenfeld, Eyal Epstein, Lilach Cherry, Hagit Achdout, Noam Erez, Boaz Politi, Yfat Yahalom-Ronen, Shay Weiss, Sharon Melamed, Tomer Israely, Ohad Mazor, Nir Paran, Efi Makdasi
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:Microbiology Spectrum
Subjects:
vaccinia virus
orthopoxviruses
neutralizing antibodies
VIG
Mpox
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01598-23

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