Association between the rs6313 polymorphism in the 5-HTR2A gene and the efficacy of antipsychotic drugs
Abstract Background Prescribing the optimal antipsychotic treatment to schizophrenia is very important as it is well established that patients have different sensitivity to the available antipsychotic drugs. The genotype of the HTR2A T102C (rs6313) polymorphism has been suggested to affect the effic...
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| Format: | Article |
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BMC
2023-09-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-023-05165-1 |
| _version_ | 1797557393390829568 |
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| author | Yulong Wang Xingru Tan Zhoufangyuan Chen Bide Zhang Yunzhi Gao Yanlong Wang |
| author_facet | Yulong Wang Xingru Tan Zhoufangyuan Chen Bide Zhang Yunzhi Gao Yanlong Wang |
| author_sort | Yulong Wang |
| collection | DOAJ |
| description | Abstract Background Prescribing the optimal antipsychotic treatment to schizophrenia is very important as it is well established that patients have different sensitivity to the available antipsychotic drugs. The genotype of the HTR2A T102C (rs6313) polymorphism has been suggested to affect the efficacy of antipsychotic drugs, but the results of different studies have been inconsistent Methods In this study, a meta-analysis was used to ascertain the association between allele and genotype polymorphism of rs6313 and the efficacy of antipsychotic drugs. Related studies publicated from January 1995 to December 2021 were retrieved from PubMed, Embase, ScienceDirect, and Web of Science databases. The correlations between allele and genotype polymorphism of rs6313 and the responder rate and scale score reduction rate of antipsychotics were analyzed. In addition, subgroup analyses were performed on time, drug, and ethnicity. Results A total of 18 studies were included. The meta-analysis showed that allele and genotype polymorphisms at the rs6313 locus overall were not associated with antipsychotic drug responder rate or scale score reduction rate. Ethnicity subgroup analysis showed that antipsychotic drugs were more effective in patients with allele T in the Caucasian population. Indian patients with the TT genotype had the lowest scale score reduction rate and poor drug treatment effect. East Asian patients with the TC genotype had better treatment effect, whereas in patients with the CC genotype, the treatment was less effective. Drug subgroup analysis showed that patients with the TC genotype treated with clozapine had the highest responder rate and score reduction rate. Conclusions The association between rs6313 polymorphism and the efficacy of antipsychotic drugs is mainly influenced by drug and ethnicity. Caucasian patients with the T allele respond better to drug therapy, and Asian patients with TC genotype. The TC genotype was also a good predictor of the efficacy of clozapine treatment. |
| first_indexed | 2024-03-10T17:16:26Z |
| format | Article |
| id | doaj.art-9ae6ee9861764e13b737768f637c6fe4 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-03-10T17:16:26Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-9ae6ee9861764e13b737768f637c6fe42023-11-20T10:29:13ZengBMCBMC Psychiatry1471-244X2023-09-0123111410.1186/s12888-023-05165-1Association between the rs6313 polymorphism in the 5-HTR2A gene and the efficacy of antipsychotic drugsYulong Wang0Xingru Tan1Zhoufangyuan Chen2Bide Zhang3Yunzhi Gao4Yanlong Wang5Lin He’s Academician Workstation of New Medicine and Clinical Translation in Jining Medical University, Jining Medical UniversityLin He’s Academician Workstation of New Medicine and Clinical Translation in Jining Medical University, Jining Medical UniversityLin He’s Academician Workstation of New Medicine and Clinical Translation in Jining Medical University, Jining Medical UniversityLin He’s Academician Workstation of New Medicine and Clinical Translation in Jining Medical University, Jining Medical UniversityLin He’s Academician Workstation of New Medicine and Clinical Translation in Jining Medical University, Jining Medical UniversityLin He’s Academician Workstation of New Medicine and Clinical Translation in Jining Medical University, Jining Medical UniversityAbstract Background Prescribing the optimal antipsychotic treatment to schizophrenia is very important as it is well established that patients have different sensitivity to the available antipsychotic drugs. The genotype of the HTR2A T102C (rs6313) polymorphism has been suggested to affect the efficacy of antipsychotic drugs, but the results of different studies have been inconsistent Methods In this study, a meta-analysis was used to ascertain the association between allele and genotype polymorphism of rs6313 and the efficacy of antipsychotic drugs. Related studies publicated from January 1995 to December 2021 were retrieved from PubMed, Embase, ScienceDirect, and Web of Science databases. The correlations between allele and genotype polymorphism of rs6313 and the responder rate and scale score reduction rate of antipsychotics were analyzed. In addition, subgroup analyses were performed on time, drug, and ethnicity. Results A total of 18 studies were included. The meta-analysis showed that allele and genotype polymorphisms at the rs6313 locus overall were not associated with antipsychotic drug responder rate or scale score reduction rate. Ethnicity subgroup analysis showed that antipsychotic drugs were more effective in patients with allele T in the Caucasian population. Indian patients with the TT genotype had the lowest scale score reduction rate and poor drug treatment effect. East Asian patients with the TC genotype had better treatment effect, whereas in patients with the CC genotype, the treatment was less effective. Drug subgroup analysis showed that patients with the TC genotype treated with clozapine had the highest responder rate and score reduction rate. Conclusions The association between rs6313 polymorphism and the efficacy of antipsychotic drugs is mainly influenced by drug and ethnicity. Caucasian patients with the T allele respond better to drug therapy, and Asian patients with TC genotype. The TC genotype was also a good predictor of the efficacy of clozapine treatment.https://doi.org/10.1186/s12888-023-05165-1Genetic polymorphismSchizophrenia5-HTR2Ars6313Antipsychotic drugs |
| spellingShingle | Yulong Wang Xingru Tan Zhoufangyuan Chen Bide Zhang Yunzhi Gao Yanlong Wang Association between the rs6313 polymorphism in the 5-HTR2A gene and the efficacy of antipsychotic drugs BMC Psychiatry Genetic polymorphism Schizophrenia 5-HTR2A rs6313 Antipsychotic drugs |
| title | Association between the rs6313 polymorphism in the 5-HTR2A gene and the efficacy of antipsychotic drugs |
| title_full | Association between the rs6313 polymorphism in the 5-HTR2A gene and the efficacy of antipsychotic drugs |
| title_fullStr | Association between the rs6313 polymorphism in the 5-HTR2A gene and the efficacy of antipsychotic drugs |
| title_full_unstemmed | Association between the rs6313 polymorphism in the 5-HTR2A gene and the efficacy of antipsychotic drugs |
| title_short | Association between the rs6313 polymorphism in the 5-HTR2A gene and the efficacy of antipsychotic drugs |
| title_sort | association between the rs6313 polymorphism in the 5 htr2a gene and the efficacy of antipsychotic drugs |
| topic | Genetic polymorphism Schizophrenia 5-HTR2A rs6313 Antipsychotic drugs |
| url | https://doi.org/10.1186/s12888-023-05165-1 |
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