Role of streptococcal infection in the acute pathology of lymphatic filariasis
Growing evidence suggest that secondary bacterial, mainly streptococcal, infections contribute significantly to recurrent episodes of acute adenolymphangitis (ADL| of filarial origin. We examined the role of group A streptococci in the progression of lymphedema in Polynesian patients with filariasis...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2000-06-01
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| Series: | Parasite |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1051/parasite/2000072091 |
| _version_ | 1797427508110426112 |
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| author | Esterre P. Plichart C. Huin-Blondey M.O. Nguyen L. |
| author_facet | Esterre P. Plichart C. Huin-Blondey M.O. Nguyen L. |
| author_sort | Esterre P. |
| collection | DOAJ |
| description | Growing evidence suggest that secondary bacterial, mainly streptococcal, infections contribute significantly to recurrent episodes of acute adenolymphangitis (ADL| of filarial origin. We examined the role of group A streptococci in the progression of lymphedema in Polynesian patients with filariasis-related ADL (22 cases) or chronic pathology (10 cases), or with erysipela (10 patients) and, as controls, in 20 healthy adults. Antistreptolysin O (ASLO) and anti-streptodornase B (ASDB) titers were systematically determined in parallel to parasitological and biochemical tests. ASLO and ASDB assays were positive in 100 % of erysipela, 75 % of filarial ADL as compared to 50 % of chronic pathology and 39 % of healthy controls. Interestingly, by opposition to ASLO titers which were not significantly different between the four groups, ASDB titers were higher in ADL (p = 0.019) and erysipela (p = 0.002) than in controls. These results support the hypothesis that recurrent streptococcal infections may have an important role in the pathogenesis of ADL in lymphatic filariasis. |
| first_indexed | 2024-03-09T08:46:01Z |
| format | Article |
| id | doaj.art-9ae702f64c1c4abfb205ff357679503b |
| institution | Directory Open Access Journal |
| issn | 1252-607X 1776-1042 |
| language | English |
| last_indexed | 2024-03-09T08:46:01Z |
| publishDate | 2000-06-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Parasite |
| spelling | doaj.art-9ae702f64c1c4abfb205ff357679503b2023-12-02T15:32:24ZengEDP SciencesParasite1252-607X1776-10422000-06-0172919410.1051/parasite/2000072091parasite2000072p91Role of streptococcal infection in the acute pathology of lymphatic filariasisEsterre P.Plichart C.Huin-Blondey M.O.Nguyen L.Growing evidence suggest that secondary bacterial, mainly streptococcal, infections contribute significantly to recurrent episodes of acute adenolymphangitis (ADL| of filarial origin. We examined the role of group A streptococci in the progression of lymphedema in Polynesian patients with filariasis-related ADL (22 cases) or chronic pathology (10 cases), or with erysipela (10 patients) and, as controls, in 20 healthy adults. Antistreptolysin O (ASLO) and anti-streptodornase B (ASDB) titers were systematically determined in parallel to parasitological and biochemical tests. ASLO and ASDB assays were positive in 100 % of erysipela, 75 % of filarial ADL as compared to 50 % of chronic pathology and 39 % of healthy controls. Interestingly, by opposition to ASLO titers which were not significantly different between the four groups, ASDB titers were higher in ADL (p = 0.019) and erysipela (p = 0.002) than in controls. These results support the hypothesis that recurrent streptococcal infections may have an important role in the pathogenesis of ADL in lymphatic filariasis.http://dx.doi.org/10.1051/parasite/2000072091lymphatic filariasisWuchereria bancroftigroup A streptococciacute adenolymphangitisFrench Polynesia |
| spellingShingle | Esterre P. Plichart C. Huin-Blondey M.O. Nguyen L. Role of streptococcal infection in the acute pathology of lymphatic filariasis Parasite lymphatic filariasis Wuchereria bancrofti group A streptococci acute adenolymphangitis French Polynesia |
| title | Role of streptococcal infection in the acute pathology of lymphatic filariasis |
| title_full | Role of streptococcal infection in the acute pathology of lymphatic filariasis |
| title_fullStr | Role of streptococcal infection in the acute pathology of lymphatic filariasis |
| title_full_unstemmed | Role of streptococcal infection in the acute pathology of lymphatic filariasis |
| title_short | Role of streptococcal infection in the acute pathology of lymphatic filariasis |
| title_sort | role of streptococcal infection in the acute pathology of lymphatic filariasis |
| topic | lymphatic filariasis Wuchereria bancrofti group A streptococci acute adenolymphangitis French Polynesia |
| url | http://dx.doi.org/10.1051/parasite/2000072091 |
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