Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis

Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis

Abstract Background Liver ischemia/reperfusion (I/R) injury is usually caused by hepatic inflow occlusion during liver surgery, and is frequently observed during war wounds and trauma. Hepatocyte ferroptosis plays a critical role in liver I/R injury, however, it remains unclear whether this process...

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Main Authors: Kai-Wei Jia, Ren-Qi Yao, Yi-Wen Fan, Ding-Ji Zhang, Ye Zhou, Min-Jun Wang, Li-Yuan Zhang, Yue Dong, Zhi-Xuan Li, Su-Yuan Wang, Mu Wang, Yun-Hui Li, Lu-Xin Zhang, Ting Lei, Liang-Chen Gui, Shan Lu, Ying-Yun Yang, Si-Xian Wang, Yi-Zhi Yu, Yong-Ming Yao, Jin Hou
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Military Medical Research
Subjects:
Ischemia/reperfusion (I/R)
DExH-box helicase 58 (DHX58)
Glutathione peroxidase 4 (GPX4)
m6A modification
YT521-B homology domain containing 2 (YTHDC2)
Online Access:https://doi.org/10.1186/s40779-024-00524-9

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