Efferocytosis is restricted by axon guidance molecule EphA4 via ERK/Stat6/MERTK signaling following brain injury

Efferocytosis is restricted by axon guidance molecule EphA4 via ERK/Stat6/MERTK signaling following brain injury

Abstract Background Efferocytosis is a process that removes apoptotic cells and cellular debris. Clearance of these cells alleviates neuroinflammation, prevents the release of inflammatory molecules, and promotes the production of anti-inflammatory cytokines to help maintain tissue homeostasis. The...

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Bibliographic Details
Main Authors: Eman Soliman, John Leonard, Erwin Kristobal Gudenschwager Basso, Ilana Gershenson, Jing Ju, Jatia Mills, Caroline de Jager, Alexandra M. Kaloss, Mohamed Elhassanny, Daniela Pereira, Michael Chen, Xia Wang, Michelle H. Theus
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Neuroinflammation
Subjects:
Efferocytosis
Neuroinflammation
Traumatic brain injury
Apoptosis
Peripheral-derived macrophages
Microglia
Online Access:https://doi.org/10.1186/s12974-023-02940-5

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