Polymyxin B and ethylenediaminetetraacetic acid act synergistically against Pseudomonas aeruginosa and Staphylococcus aureus

Polymyxin B and ethylenediaminetetraacetic acid act synergistically against Pseudomonas aeruginosa and Staphylococcus aureus

ABSTRACTPolymyxin B and ethylenediaminetetraacetic acid are antimicrobials possessing antibiofilm activity. They act by displacement and chelation, respectively, of divalent cations in bacterial membranes and may therefore act synergistically when applied in combination. If so, this combination of a...

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Bibliographic Details
Main Authors: Samuel J. M. Hale, Alan J. Cameron, Christian A. Lux, Kristi Biswas, Raymond Kim, Mark O'Carroll, Paul W. R. Harris, Richard G. Douglas, Brett Wagner Mackenzie
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:Microbiology Spectrum
Subjects:
biofilms
cystic fibrosis
EDTA
polymyxins
Pseudomonas aeruginosa
Staphylococcus aureus
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01709-23

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