Morphine as a suspect of aiding the propagation of cancer cells
Controlling pain in cancer patients is important for several reasons including patient quality of life (QOL). In moderate-to-severe cancer-pain management, opioid analgesics are indispensable. Among these, morphine is the most representative. Unfortunately, many studies have shown that morphine is p...
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| Format: | Article |
| Language: | English |
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Kosin University College of Medicine
2017-12-01
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| Series: | Kosin Medical Journal |
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| Online Access: | http://www.kosinmedj.org/upload/pdf/ksmc032-02-02.pdf |
| _version_ | 1828303414778396672 |
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| author | Yusom Shin |
| author_facet | Yusom Shin |
| author_sort | Yusom Shin |
| collection | DOAJ |
| description | Controlling pain in cancer patients is important for several reasons including patient quality of life (QOL). In moderate-to-severe cancer-pain management, opioid analgesics are indispensable. Among these, morphine is the most representative. Unfortunately, many studies have shown that morphine is potentially associated with cancer growth, recurrence, and metastasis. Specifically, in animal as well as in vivo and in vitro studies, morphine has been demonstrated to have possibly positive effects on cancer progression. However, those effects have not yet been confirmed as entirely harmful, for several reasons: the results of animal and laboratory research have not been subjected to clinical trials; there are as yet no well-designed clinical studies, and indeed, some studies have shown that morphine can have negative, suppression effects on tumor growth. This review paper will present some of the data on the potentially positive relationships between morphine and cancer. It should not be forgotten, though, that such relationships remain controversial, and that pain itself promotes cancer progression. |
| first_indexed | 2024-04-13T13:53:41Z |
| format | Article |
| id | doaj.art-9af3ad572b4848db94c7783ed4242d6e |
| institution | Directory Open Access Journal |
| issn | 2005-9531 2586-7024 |
| language | English |
| last_indexed | 2024-04-13T13:53:41Z |
| publishDate | 2017-12-01 |
| publisher | Kosin University College of Medicine |
| record_format | Article |
| series | Kosin Medical Journal |
| spelling | doaj.art-9af3ad572b4848db94c7783ed4242d6e2022-12-22T02:44:16ZengKosin University College of MedicineKosin Medical Journal2005-95312586-70242017-12-0132216416910.7180/kmj.2017.32.2.164195Morphine as a suspect of aiding the propagation of cancer cellsYusom ShinControlling pain in cancer patients is important for several reasons including patient quality of life (QOL). In moderate-to-severe cancer-pain management, opioid analgesics are indispensable. Among these, morphine is the most representative. Unfortunately, many studies have shown that morphine is potentially associated with cancer growth, recurrence, and metastasis. Specifically, in animal as well as in vivo and in vitro studies, morphine has been demonstrated to have possibly positive effects on cancer progression. However, those effects have not yet been confirmed as entirely harmful, for several reasons: the results of animal and laboratory research have not been subjected to clinical trials; there are as yet no well-designed clinical studies, and indeed, some studies have shown that morphine can have negative, suppression effects on tumor growth. This review paper will present some of the data on the potentially positive relationships between morphine and cancer. It should not be forgotten, though, that such relationships remain controversial, and that pain itself promotes cancer progression.http://www.kosinmedj.org/upload/pdf/ksmc032-02-02.pdfmetastasismorphineopioid |
| spellingShingle | Yusom Shin Morphine as a suspect of aiding the propagation of cancer cells Kosin Medical Journal metastasis morphine opioid |
| title | Morphine as a suspect of aiding the propagation of cancer cells |
| title_full | Morphine as a suspect of aiding the propagation of cancer cells |
| title_fullStr | Morphine as a suspect of aiding the propagation of cancer cells |
| title_full_unstemmed | Morphine as a suspect of aiding the propagation of cancer cells |
| title_short | Morphine as a suspect of aiding the propagation of cancer cells |
| title_sort | morphine as a suspect of aiding the propagation of cancer cells |
| topic | metastasis morphine opioid |
| url | http://www.kosinmedj.org/upload/pdf/ksmc032-02-02.pdf |
| work_keys_str_mv | AT yusomshin morphineasasuspectofaidingthepropagationofcancercells |