Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland

Water-clear cell adenoma of the parathyroid gland is a rare neoplasm that consists of cells with abundant clear-pink cytoplasm. There have only been 19 cases reported in the English literature. Here we report a case of water-clear cell adenoma of the mediastinal parathyroid gland. A 70-year-old male...

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Main Authors: Deniz ARIK, Emine DÜNDAR, Evrim YILMAZ, Cumhur SİVRİKOZ
Format: Article
Language:English
Published: Federation of Turkish Pathology Societies 2019-05-01
Series:Türk Patoloji Dergisi
Subjects:
Online Access: http://www.turkjpath.org/pdf.php3?id=1844
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author Deniz ARIK
Emine DÜNDAR
Evrim YILMAZ
Cumhur SİVRİKOZ
author_facet Deniz ARIK
Emine DÜNDAR
Evrim YILMAZ
Cumhur SİVRİKOZ
author_sort Deniz ARIK
collection DOAJ
description Water-clear cell adenoma of the parathyroid gland is a rare neoplasm that consists of cells with abundant clear-pink cytoplasm. There have only been 19 cases reported in the English literature. Here we report a case of water-clear cell adenoma of the mediastinal parathyroid gland. A 70-year-old male patient presented to the hospital with back pain and a mediastinal mass 6 cm in size was detected. After excision and microscopic evaluation, uniform, large clear cells with fine cytoplasmic vacuolization, without nuclear atypia, and arranged in solid and acinar patterns were revealed. The cells formed nests that were separated by fine fibrovascular septae and stained positively with anti-parathyroid hormone. To the best of our knowledge, this has not been previously reported in this location. In the differential diagnosis of clear cell lesions of the mediastinum, water-clear cell parathyroid adenoma should be considered.
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spelling doaj.art-9af63ff1f0224ff4941aa255c496f2122023-02-15T16:07:19ZengFederation of Turkish Pathology SocietiesTürk Patoloji Dergisi1018-56151309-57302019-05-0135215716110.5146/tjpath.2017.01407Water-Clear Cell Adenoma of the Mediastinal Parathyroid GlandDeniz ARIKEmine DÜNDAREvrim YILMAZCumhur SİVRİKOZWater-clear cell adenoma of the parathyroid gland is a rare neoplasm that consists of cells with abundant clear-pink cytoplasm. There have only been 19 cases reported in the English literature. Here we report a case of water-clear cell adenoma of the mediastinal parathyroid gland. A 70-year-old male patient presented to the hospital with back pain and a mediastinal mass 6 cm in size was detected. After excision and microscopic evaluation, uniform, large clear cells with fine cytoplasmic vacuolization, without nuclear atypia, and arranged in solid and acinar patterns were revealed. The cells formed nests that were separated by fine fibrovascular septae and stained positively with anti-parathyroid hormone. To the best of our knowledge, this has not been previously reported in this location. In the differential diagnosis of clear cell lesions of the mediastinum, water-clear cell parathyroid adenoma should be considered. http://www.turkjpath.org/pdf.php3?id=1844 Water-clear cellAdenomaEctopic tissueMediastinumParathyroid gland
spellingShingle Deniz ARIK
Emine DÜNDAR
Evrim YILMAZ
Cumhur SİVRİKOZ
Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland
Türk Patoloji Dergisi
Water-clear cell
Adenoma
Ectopic tissue
Mediastinum
Parathyroid gland
title Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland
title_full Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland
title_fullStr Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland
title_full_unstemmed Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland
title_short Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland
title_sort water clear cell adenoma of the mediastinal parathyroid gland
topic Water-clear cell
Adenoma
Ectopic tissue
Mediastinum
Parathyroid gland
url http://www.turkjpath.org/pdf.php3?id=1844
work_keys_str_mv AT denizarik waterclearcelladenomaofthemediastinalparathyroidgland
AT eminedundar waterclearcelladenomaofthemediastinalparathyroidgland
AT evrimyilmaz waterclearcelladenomaofthemediastinalparathyroidgland
AT cumhursivrikoz waterclearcelladenomaofthemediastinalparathyroidgland