Glycans and Glycan-Binding Proteins as Regulators and Potential Targets in Leukocyte Recruitment
Leukocyte recruitment is a highly controlled cascade of interactions between proteins expressed by the endothelium and circulating leukocytes. The involvement of glycans and glycan-binding proteins in the leukocyte recruitment cascade has been well-characterised. However, our understanding of these...
| Huvudupphovsmän: | , |
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| Materialtyp: | Artikel |
| Språk: | English |
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Frontiers Media S.A.
2021-02-01
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| Serie: | Frontiers in Cell and Developmental Biology |
| Ämnen: | |
| Länkar: | https://www.frontiersin.org/articles/10.3389/fcell.2021.624082/full |
| _version_ | 1829510945719713792 |
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| author | Franziska Krautter Asif J. Iqbal |
| author_facet | Franziska Krautter Asif J. Iqbal |
| author_sort | Franziska Krautter |
| collection | DOAJ |
| description | Leukocyte recruitment is a highly controlled cascade of interactions between proteins expressed by the endothelium and circulating leukocytes. The involvement of glycans and glycan-binding proteins in the leukocyte recruitment cascade has been well-characterised. However, our understanding of these interactions and their regulation has expanded substantially in recent years to include novel lectins and regulatory pathways. In this review, we discuss the role of glycans and glycan-binding proteins, mediating the interactions between endothelium and leukocytes both directly and indirectly. We also highlight recent findings of key enzymes involved in glycosylation which affect leukocyte recruitment. Finally, we investigate the potential of glycans and glycan binding proteins as therapeutic targets to modulate leukocyte recruitment and transmigration in inflammation. |
| first_indexed | 2024-12-16T12:15:22Z |
| format | Article |
| id | doaj.art-9af66e84129e4195a96ced9aadae9e24 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-16T12:15:22Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-9af66e84129e4195a96ced9aadae9e242022-12-21T22:32:07ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-02-01910.3389/fcell.2021.624082624082Glycans and Glycan-Binding Proteins as Regulators and Potential Targets in Leukocyte RecruitmentFranziska KrautterAsif J. IqbalLeukocyte recruitment is a highly controlled cascade of interactions between proteins expressed by the endothelium and circulating leukocytes. The involvement of glycans and glycan-binding proteins in the leukocyte recruitment cascade has been well-characterised. However, our understanding of these interactions and their regulation has expanded substantially in recent years to include novel lectins and regulatory pathways. In this review, we discuss the role of glycans and glycan-binding proteins, mediating the interactions between endothelium and leukocytes both directly and indirectly. We also highlight recent findings of key enzymes involved in glycosylation which affect leukocyte recruitment. Finally, we investigate the potential of glycans and glycan binding proteins as therapeutic targets to modulate leukocyte recruitment and transmigration in inflammation.https://www.frontiersin.org/articles/10.3389/fcell.2021.624082/fullglycanglycan-binding proteinleukocyte recruitmenttransmigrationlectinsglycomimetics |
| spellingShingle | Franziska Krautter Asif J. Iqbal Glycans and Glycan-Binding Proteins as Regulators and Potential Targets in Leukocyte Recruitment Frontiers in Cell and Developmental Biology glycan glycan-binding protein leukocyte recruitment transmigration lectins glycomimetics |
| title | Glycans and Glycan-Binding Proteins as Regulators and Potential Targets in Leukocyte Recruitment |
| title_full | Glycans and Glycan-Binding Proteins as Regulators and Potential Targets in Leukocyte Recruitment |
| title_fullStr | Glycans and Glycan-Binding Proteins as Regulators and Potential Targets in Leukocyte Recruitment |
| title_full_unstemmed | Glycans and Glycan-Binding Proteins as Regulators and Potential Targets in Leukocyte Recruitment |
| title_short | Glycans and Glycan-Binding Proteins as Regulators and Potential Targets in Leukocyte Recruitment |
| title_sort | glycans and glycan binding proteins as regulators and potential targets in leukocyte recruitment |
| topic | glycan glycan-binding protein leukocyte recruitment transmigration lectins glycomimetics |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.624082/full |
| work_keys_str_mv | AT franziskakrautter glycansandglycanbindingproteinsasregulatorsandpotentialtargetsinleukocyterecruitment AT asifjiqbal glycansandglycanbindingproteinsasregulatorsandpotentialtargetsinleukocyterecruitment |