Assessing the Risk of Nodal Metastases in Canine Integumentary Mast Cell Tumors: Is Sentinel Lymph Node Biopsy Always Necessary?
The recent literature supports the sentinel lymph node (SLN) biopsy in dogs with MCT due to discrepancy with the regional lymph node and the high percentage of occult metastasis. However, the SLN biopsy includes additional anesthesiologic, diagnostic, and surgical procedures, and additional costs. T...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-08-01
|
Series: | Animals |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-2615/11/8/2373 |
_version_ | 1797524922031931392 |
---|---|
author | Roberta Ferrari Patrizia Boracchi Lavinia Elena Chiti Martina Manfredi Chiara Giudice Donatella De Zani Carlotta Spediacci Camilla Recordati Valeria Grieco Elisa Maria Gariboldi Damiano Stefanello |
author_facet | Roberta Ferrari Patrizia Boracchi Lavinia Elena Chiti Martina Manfredi Chiara Giudice Donatella De Zani Carlotta Spediacci Camilla Recordati Valeria Grieco Elisa Maria Gariboldi Damiano Stefanello |
author_sort | Roberta Ferrari |
collection | DOAJ |
description | The recent literature supports the sentinel lymph node (SLN) biopsy in dogs with MCT due to discrepancy with the regional lymph node and the high percentage of occult metastasis. However, the SLN biopsy includes additional anesthesiologic, diagnostic, and surgical procedures, and additional costs. The study aimed to assess the association between clinicopathological variables and SLN status, determining the identification of dogs at lower risk of SLN metastases. Dogs with integumentary MCT were admitted to the lymphoscintigraphic mapping and subsequent biopsy of SLN. The association between clinicopathological variables of MCT and SLN status was statistically tested, both considering occult and overt metastasis together (HN2-HN3) and overt metastasis (HN3) alone. Fifty low-grade cutaneous MCT and 16 subcutaneous MCT were included. A small to moderate association between integumentary MCT ≥ 3 cm and HN2-HN3 SLN was found. A strong association of integumentary MCT dimension and subcutaneous MCT with HN3 SLN occurred. Dimension of low-grade cutaneous and subcutaneous MCT seems to correlate with SLN status, but additional study should confirm this data before excluding small MCT to the SLN biopsy. On the contrary, the study results induce a solid suggestion for mapping and biopsy of the SLN in MCT > 3 cm and subcutaneous MCT. |
first_indexed | 2024-03-10T09:04:29Z |
format | Article |
id | doaj.art-9af76b38a4914bc6b4e1d19fe6430cc9 |
institution | Directory Open Access Journal |
issn | 2076-2615 |
language | English |
last_indexed | 2024-03-10T09:04:29Z |
publishDate | 2021-08-01 |
publisher | MDPI AG |
record_format | Article |
series | Animals |
spelling | doaj.art-9af76b38a4914bc6b4e1d19fe6430cc92023-11-22T06:31:10ZengMDPI AGAnimals2076-26152021-08-01118237310.3390/ani11082373Assessing the Risk of Nodal Metastases in Canine Integumentary Mast Cell Tumors: Is Sentinel Lymph Node Biopsy Always Necessary?Roberta Ferrari0Patrizia Boracchi1Lavinia Elena Chiti2Martina Manfredi3Chiara Giudice4Donatella De Zani5Carlotta Spediacci6Camilla Recordati7Valeria Grieco8Elisa Maria Gariboldi9Damiano Stefanello10Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, ItalyDipartimento di Scienze Cliniche e di Comunità, Laboratorio di Statistica Medica, Biometria ed Eopidemiologia “G.A. Maccacaro”, Università degli Studi di Milano, 20122 Milano, ItalyDipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, ItalyDipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, ItalyDipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, ItalyCentro Clinico–Veterinario e Zootecnico–Sperimentale, Veterinary Teaching Hospital, Università degli Studi di Milano, 26900 Lodi, ItalyDipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, ItalyDipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, ItalyDipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, ItalyCentro Clinico–Veterinario e Zootecnico–Sperimentale, Veterinary Teaching Hospital, Università degli Studi di Milano, 26900 Lodi, ItalyDipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, ItalyThe recent literature supports the sentinel lymph node (SLN) biopsy in dogs with MCT due to discrepancy with the regional lymph node and the high percentage of occult metastasis. However, the SLN biopsy includes additional anesthesiologic, diagnostic, and surgical procedures, and additional costs. The study aimed to assess the association between clinicopathological variables and SLN status, determining the identification of dogs at lower risk of SLN metastases. Dogs with integumentary MCT were admitted to the lymphoscintigraphic mapping and subsequent biopsy of SLN. The association between clinicopathological variables of MCT and SLN status was statistically tested, both considering occult and overt metastasis together (HN2-HN3) and overt metastasis (HN3) alone. Fifty low-grade cutaneous MCT and 16 subcutaneous MCT were included. A small to moderate association between integumentary MCT ≥ 3 cm and HN2-HN3 SLN was found. A strong association of integumentary MCT dimension and subcutaneous MCT with HN3 SLN occurred. Dimension of low-grade cutaneous and subcutaneous MCT seems to correlate with SLN status, but additional study should confirm this data before excluding small MCT to the SLN biopsy. On the contrary, the study results induce a solid suggestion for mapping and biopsy of the SLN in MCT > 3 cm and subcutaneous MCT.https://www.mdpi.com/2076-2615/11/8/2373mast cell tumorsentinel lymph nodemetastasisstaginglymphoscintigraphy |
spellingShingle | Roberta Ferrari Patrizia Boracchi Lavinia Elena Chiti Martina Manfredi Chiara Giudice Donatella De Zani Carlotta Spediacci Camilla Recordati Valeria Grieco Elisa Maria Gariboldi Damiano Stefanello Assessing the Risk of Nodal Metastases in Canine Integumentary Mast Cell Tumors: Is Sentinel Lymph Node Biopsy Always Necessary? Animals mast cell tumor sentinel lymph node metastasis staging lymphoscintigraphy |
title | Assessing the Risk of Nodal Metastases in Canine Integumentary Mast Cell Tumors: Is Sentinel Lymph Node Biopsy Always Necessary? |
title_full | Assessing the Risk of Nodal Metastases in Canine Integumentary Mast Cell Tumors: Is Sentinel Lymph Node Biopsy Always Necessary? |
title_fullStr | Assessing the Risk of Nodal Metastases in Canine Integumentary Mast Cell Tumors: Is Sentinel Lymph Node Biopsy Always Necessary? |
title_full_unstemmed | Assessing the Risk of Nodal Metastases in Canine Integumentary Mast Cell Tumors: Is Sentinel Lymph Node Biopsy Always Necessary? |
title_short | Assessing the Risk of Nodal Metastases in Canine Integumentary Mast Cell Tumors: Is Sentinel Lymph Node Biopsy Always Necessary? |
title_sort | assessing the risk of nodal metastases in canine integumentary mast cell tumors is sentinel lymph node biopsy always necessary |
topic | mast cell tumor sentinel lymph node metastasis staging lymphoscintigraphy |
url | https://www.mdpi.com/2076-2615/11/8/2373 |
work_keys_str_mv | AT robertaferrari assessingtheriskofnodalmetastasesincanineintegumentarymastcelltumorsissentinellymphnodebiopsyalwaysnecessary AT patriziaboracchi assessingtheriskofnodalmetastasesincanineintegumentarymastcelltumorsissentinellymphnodebiopsyalwaysnecessary AT laviniaelenachiti assessingtheriskofnodalmetastasesincanineintegumentarymastcelltumorsissentinellymphnodebiopsyalwaysnecessary AT martinamanfredi assessingtheriskofnodalmetastasesincanineintegumentarymastcelltumorsissentinellymphnodebiopsyalwaysnecessary AT chiaragiudice assessingtheriskofnodalmetastasesincanineintegumentarymastcelltumorsissentinellymphnodebiopsyalwaysnecessary AT donatelladezani assessingtheriskofnodalmetastasesincanineintegumentarymastcelltumorsissentinellymphnodebiopsyalwaysnecessary AT carlottaspediacci assessingtheriskofnodalmetastasesincanineintegumentarymastcelltumorsissentinellymphnodebiopsyalwaysnecessary AT camillarecordati assessingtheriskofnodalmetastasesincanineintegumentarymastcelltumorsissentinellymphnodebiopsyalwaysnecessary AT valeriagrieco assessingtheriskofnodalmetastasesincanineintegumentarymastcelltumorsissentinellymphnodebiopsyalwaysnecessary AT elisamariagariboldi assessingtheriskofnodalmetastasesincanineintegumentarymastcelltumorsissentinellymphnodebiopsyalwaysnecessary AT damianostefanello assessingtheriskofnodalmetastasesincanineintegumentarymastcelltumorsissentinellymphnodebiopsyalwaysnecessary |