PBRM1 suppresses tumor growth as a novel p53 acetylation reader
The reader(s) for acetylated tumor antigen p53 remains elusive. Here, PBRM1 (polybromo-1) is identified as a reader for acetylated lysine382 on p53 through its bromodomain 4 (BD4). PBRM1 BD4 mutants fail to support p53 transcriptional activity and suppress tumor growth. Thus PBRM1 suppresses tumor g...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-05-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1729680 |
| _version_ | 1797677157722357760 |
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| author | Weijia Cai Liya Su Haifeng Yang |
| author_facet | Weijia Cai Liya Su Haifeng Yang |
| author_sort | Weijia Cai |
| collection | DOAJ |
| description | The reader(s) for acetylated tumor antigen p53 remains elusive. Here, PBRM1 (polybromo-1) is identified as a reader for acetylated lysine382 on p53 through its bromodomain 4 (BD4). PBRM1 BD4 mutants fail to support p53 transcriptional activity and suppress tumor growth. Thus PBRM1 suppresses tumor growth through p53 in kidney cancer. |
| first_indexed | 2024-03-11T22:40:59Z |
| format | Article |
| id | doaj.art-9af94ab5283b44b98fa0f17a13184f27 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:59Z |
| publishDate | 2020-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-9af94ab5283b44b98fa0f17a13184f272023-09-22T09:11:01ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562020-05-017310.1080/23723556.2020.17296801729680PBRM1 suppresses tumor growth as a novel p53 acetylation readerWeijia Cai0Liya Su1Haifeng Yang2Thomas Jefferson UniversityThomas Jefferson UniversityThomas Jefferson UniversityThe reader(s) for acetylated tumor antigen p53 remains elusive. Here, PBRM1 (polybromo-1) is identified as a reader for acetylated lysine382 on p53 through its bromodomain 4 (BD4). PBRM1 BD4 mutants fail to support p53 transcriptional activity and suppress tumor growth. Thus PBRM1 suppresses tumor growth through p53 in kidney cancer.http://dx.doi.org/10.1080/23723556.2020.1729680pbrm1p53renal cancerlysine acetylation |
| spellingShingle | Weijia Cai Liya Su Haifeng Yang PBRM1 suppresses tumor growth as a novel p53 acetylation reader Molecular & Cellular Oncology pbrm1 p53 renal cancer lysine acetylation |
| title | PBRM1 suppresses tumor growth as a novel p53 acetylation reader |
| title_full | PBRM1 suppresses tumor growth as a novel p53 acetylation reader |
| title_fullStr | PBRM1 suppresses tumor growth as a novel p53 acetylation reader |
| title_full_unstemmed | PBRM1 suppresses tumor growth as a novel p53 acetylation reader |
| title_short | PBRM1 suppresses tumor growth as a novel p53 acetylation reader |
| title_sort | pbrm1 suppresses tumor growth as a novel p53 acetylation reader |
| topic | pbrm1 p53 renal cancer lysine acetylation |
| url | http://dx.doi.org/10.1080/23723556.2020.1729680 |
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