Physicochemical Characteristics and Hydrolytic Degradation of Polylactic Acid Dermal Fillers: A Comparative Study
Dermal fillers have gained significant attention in the field of aesthetic medicine due to their ability to restore volume and correct facial wrinkles. Even though such formulations have similar compositions, they can have different microstructure and molecular characteristics, which in turn affect...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/10/4/110 |
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| author | Nikita G. Sedush Kirill T. Kalinin Pavel N. Azarkevich Antonina A. Gorskaya |
| author_facet | Nikita G. Sedush Kirill T. Kalinin Pavel N. Azarkevich Antonina A. Gorskaya |
| author_sort | Nikita G. Sedush |
| collection | DOAJ |
| description | Dermal fillers have gained significant attention in the field of aesthetic medicine due to their ability to restore volume and correct facial wrinkles. Even though such formulations have similar compositions, they can have different microstructure and molecular characteristics, which in turn affect the biodegradation profile. This study presents the results of an investigation of the physicochemical characteristics of four dermal fillers from different manufacturers (Sculptra<sup>®</sup>, Gana V<sup>®</sup>, AestheFill<sup>®</sup>, and Repart PLA<sup>®</sup>). The molecular and supramolecular characteristics of polylactic acid (L/D isomer ratio, molecular weight, degree of crystallinity), the morphology and size of PLA microparticles were determined. Hydrolytic degradation studies in phosphate buffer revealed differences in the rate of molecular weight reduction in the polymer. The obtained data may be important for the analysis and interpretation of the results of biological studies and clinical outcomes of the PLA dermal fillers. |
| first_indexed | 2024-03-11T00:01:29Z |
| format | Article |
| id | doaj.art-9afbb62c5af145dc90c6b781d537b561 |
| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-03-11T00:01:29Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj.art-9afbb62c5af145dc90c6b781d537b5612023-11-19T00:43:45ZengMDPI AGCosmetics2079-92842023-08-0110411010.3390/cosmetics10040110Physicochemical Characteristics and Hydrolytic Degradation of Polylactic Acid Dermal Fillers: A Comparative StudyNikita G. Sedush0Kirill T. Kalinin1Pavel N. Azarkevich2Antonina A. Gorskaya3Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, Moscow 117393, RussiaEnikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, Moscow 117393, RussiaEnikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, Moscow 117393, RussiaNeroly Ltd., Nizhny Novgorod 603155, RussiaDermal fillers have gained significant attention in the field of aesthetic medicine due to their ability to restore volume and correct facial wrinkles. Even though such formulations have similar compositions, they can have different microstructure and molecular characteristics, which in turn affect the biodegradation profile. This study presents the results of an investigation of the physicochemical characteristics of four dermal fillers from different manufacturers (Sculptra<sup>®</sup>, Gana V<sup>®</sup>, AestheFill<sup>®</sup>, and Repart PLA<sup>®</sup>). The molecular and supramolecular characteristics of polylactic acid (L/D isomer ratio, molecular weight, degree of crystallinity), the morphology and size of PLA microparticles were determined. Hydrolytic degradation studies in phosphate buffer revealed differences in the rate of molecular weight reduction in the polymer. The obtained data may be important for the analysis and interpretation of the results of biological studies and clinical outcomes of the PLA dermal fillers.https://www.mdpi.com/2079-9284/10/4/110biodegradable polymersdermal fillerpolylactidemicroparticles |
| spellingShingle | Nikita G. Sedush Kirill T. Kalinin Pavel N. Azarkevich Antonina A. Gorskaya Physicochemical Characteristics and Hydrolytic Degradation of Polylactic Acid Dermal Fillers: A Comparative Study Cosmetics biodegradable polymers dermal filler polylactide microparticles |
| title | Physicochemical Characteristics and Hydrolytic Degradation of Polylactic Acid Dermal Fillers: A Comparative Study |
| title_full | Physicochemical Characteristics and Hydrolytic Degradation of Polylactic Acid Dermal Fillers: A Comparative Study |
| title_fullStr | Physicochemical Characteristics and Hydrolytic Degradation of Polylactic Acid Dermal Fillers: A Comparative Study |
| title_full_unstemmed | Physicochemical Characteristics and Hydrolytic Degradation of Polylactic Acid Dermal Fillers: A Comparative Study |
| title_short | Physicochemical Characteristics and Hydrolytic Degradation of Polylactic Acid Dermal Fillers: A Comparative Study |
| title_sort | physicochemical characteristics and hydrolytic degradation of polylactic acid dermal fillers a comparative study |
| topic | biodegradable polymers dermal filler polylactide microparticles |
| url | https://www.mdpi.com/2079-9284/10/4/110 |
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