Understanding IGF-II Action through Insights into Receptor Binding and Activation

Understanding IGF-II Action through Insights into Receptor Binding and Activation

The insulin-like growth factor (IGF) system regulates metabolic and mitogenic signaling through an intricate network of related receptors and hormones. IGF-II is one of several hormones within this system that primarily regulates mitogenic functions and is especially important during fetal growth an...

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Bibliographic Details
Main Authors: Andrew J. Blyth, Nicholas S. Kirk, Briony E. Forbes
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
IGF-II
insulin-like growth factor
IGF-1R
insulin receptor
IR-A
structural studies
Online Access:https://www.mdpi.com/2073-4409/9/10/2276

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