Polymorphisms in Genes Involved in Inflammation and Periodontitis: A Narrative Review
Current evidence pinpoints that the variability in periodontitis traits in humans may be attributable to genetic factors. Different allelic variants can result in alterations in tissue structure, antibody responses and inflammatory mediators. Consequently, genetic variations may act as protective or...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/4/552 |
| _version_ | 1797436700644868096 |
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| author | Aniela Brodzikowska Bartłomiej Górski |
| author_facet | Aniela Brodzikowska Bartłomiej Górski |
| author_sort | Aniela Brodzikowska |
| collection | DOAJ |
| description | Current evidence pinpoints that the variability in periodontitis traits in humans may be attributable to genetic factors. Different allelic variants can result in alterations in tissue structure, antibody responses and inflammatory mediators. Consequently, genetic variations may act as protective or risk factors for periodontal diseases. A number of features of the inflammatory and immune response that seem to play a role in the development of periodontitis have a clearly established genetic basis. Identifying genes that contribute to the pathogenesis of periodontitis may be utilized for risk assessment in both aggressive and chronic periodontitis. The aim of this narrative review is to summarize the role of polymorphisms in genes involved in inflammation and periodontitis, including cellular receptors, tissue compatibility antigens, antibodies and cytokines. |
| first_indexed | 2024-03-09T11:06:21Z |
| format | Article |
| id | doaj.art-9afe831fc13840e99553c0a511b66c19 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T11:06:21Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-9afe831fc13840e99553c0a511b66c192023-12-01T00:56:44ZengMDPI AGBiomolecules2218-273X2022-04-0112455210.3390/biom12040552Polymorphisms in Genes Involved in Inflammation and Periodontitis: A Narrative ReviewAniela Brodzikowska0Bartłomiej Górski1Department of Conservative Dentistry, Medical University of Warsaw, 02097 Warsaw, PolandDepartment of Periodontology and Oral Mucosa Diseases, Medical University of Warsaw, 02097 Warsaw, PolandCurrent evidence pinpoints that the variability in periodontitis traits in humans may be attributable to genetic factors. Different allelic variants can result in alterations in tissue structure, antibody responses and inflammatory mediators. Consequently, genetic variations may act as protective or risk factors for periodontal diseases. A number of features of the inflammatory and immune response that seem to play a role in the development of periodontitis have a clearly established genetic basis. Identifying genes that contribute to the pathogenesis of periodontitis may be utilized for risk assessment in both aggressive and chronic periodontitis. The aim of this narrative review is to summarize the role of polymorphisms in genes involved in inflammation and periodontitis, including cellular receptors, tissue compatibility antigens, antibodies and cytokines.https://www.mdpi.com/2218-273X/12/4/552polymorphismsperiodontitis |
| spellingShingle | Aniela Brodzikowska Bartłomiej Górski Polymorphisms in Genes Involved in Inflammation and Periodontitis: A Narrative Review Biomolecules polymorphisms periodontitis |
| title | Polymorphisms in Genes Involved in Inflammation and Periodontitis: A Narrative Review |
| title_full | Polymorphisms in Genes Involved in Inflammation and Periodontitis: A Narrative Review |
| title_fullStr | Polymorphisms in Genes Involved in Inflammation and Periodontitis: A Narrative Review |
| title_full_unstemmed | Polymorphisms in Genes Involved in Inflammation and Periodontitis: A Narrative Review |
| title_short | Polymorphisms in Genes Involved in Inflammation and Periodontitis: A Narrative Review |
| title_sort | polymorphisms in genes involved in inflammation and periodontitis a narrative review |
| topic | polymorphisms periodontitis |
| url | https://www.mdpi.com/2218-273X/12/4/552 |
| work_keys_str_mv | AT anielabrodzikowska polymorphismsingenesinvolvedininflammationandperiodontitisanarrativereview AT bartłomiejgorski polymorphismsingenesinvolvedininflammationandperiodontitisanarrativereview |