Fascin expression in pleomorphic adenoma and mucoepidermoid carcinoma
Background: Salivary gland tumors constitute an important part of oral and maxillofacial pathology. Pleomorphic adenoma (PA) and mucoepidermoid carcinoma (MEC) are the most common benign and malignant salivary gland tumors. Fascin is an actin-bundling protein that increases the motility of normal an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Dental Research Journal |
| Subjects: | |
| Online Access: | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2014;volume=11;issue=3;spage=370;epage=374;aulast=Rahrotaban |
| _version_ | 1818951315943849984 |
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| author | Sedigheh Rahrotaban Faezeh Azmoudeh Seyedeh Mahboubeh Kiyani |
| author_facet | Sedigheh Rahrotaban Faezeh Azmoudeh Seyedeh Mahboubeh Kiyani |
| author_sort | Sedigheh Rahrotaban |
| collection | DOAJ |
| description | Background: Salivary gland tumors constitute an important part of oral and maxillofacial pathology. Pleomorphic adenoma (PA) and mucoepidermoid carcinoma (MEC) are the most common benign and malignant salivary gland tumors. Fascin is an actin-bundling protein that increases the motility of normal and transformed epithelial cells. The aims of the study were to determine the expression of fascin in these tumors and to determine its role in their progression.
Materials and Methods: A total of 40 formalin-fixed, paraffin-embedded tissue blocks of PA, and 20 blocks of MEC were included in this study. Diagnostic confirmation was performed through examination of hematoxylin and eosin sections. Both tumors were immunohistochemically analyzed for the presence of fascin using Avidin-Biotin complex method and evaluated via light microscope by 2 independent observers. Statistical analysis was performed using Kruskal-Wallis and Chi-square tests with significant level of P < 0.05.
Results: In both the tumors, the percentage of stained cells was significantly correlated with intensity of staining (P = 0.01 in PA and P = 0.00 in MEC). In PA, statistical analysis showed a significant direct correlation between percentage of stained cells and recurrence (P = 0.00).
There was no significant correlation between intensity and percentage of staining with clinicopathologic factors in MEC.
Conclusion: Fascin might be a useful marker for recurrence of PAs and patients with high fascin expression in primary PA should be followed up periodically to detect potential recurrence as soon as possible. |
| first_indexed | 2024-12-20T09:32:32Z |
| format | Article |
| id | doaj.art-9aff52ea06df4179a51b237ab2c1d682 |
| institution | Directory Open Access Journal |
| issn | 1735-3327 2008-0255 |
| language | English |
| last_indexed | 2024-12-20T09:32:32Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dental Research Journal |
| spelling | doaj.art-9aff52ea06df4179a51b237ab2c1d6822022-12-21T19:45:04ZengWolters Kluwer Medknow PublicationsDental Research Journal1735-33272008-02552014-01-0111337037410.4103/1735-3327.135908Fascin expression in pleomorphic adenoma and mucoepidermoid carcinomaSedigheh RahrotabanFaezeh AzmoudehSeyedeh Mahboubeh KiyaniBackground: Salivary gland tumors constitute an important part of oral and maxillofacial pathology. Pleomorphic adenoma (PA) and mucoepidermoid carcinoma (MEC) are the most common benign and malignant salivary gland tumors. Fascin is an actin-bundling protein that increases the motility of normal and transformed epithelial cells. The aims of the study were to determine the expression of fascin in these tumors and to determine its role in their progression. Materials and Methods: A total of 40 formalin-fixed, paraffin-embedded tissue blocks of PA, and 20 blocks of MEC were included in this study. Diagnostic confirmation was performed through examination of hematoxylin and eosin sections. Both tumors were immunohistochemically analyzed for the presence of fascin using Avidin-Biotin complex method and evaluated via light microscope by 2 independent observers. Statistical analysis was performed using Kruskal-Wallis and Chi-square tests with significant level of P < 0.05. Results: In both the tumors, the percentage of stained cells was significantly correlated with intensity of staining (P = 0.01 in PA and P = 0.00 in MEC). In PA, statistical analysis showed a significant direct correlation between percentage of stained cells and recurrence (P = 0.00). There was no significant correlation between intensity and percentage of staining with clinicopathologic factors in MEC. Conclusion: Fascin might be a useful marker for recurrence of PAs and patients with high fascin expression in primary PA should be followed up periodically to detect potential recurrence as soon as possible.http://www.drjjournal.net/article.asp?issn=1735-3327;year=2014;volume=11;issue=3;spage=370;epage=374;aulast=RahrotabanBenignimmunohistochemistrymalignantsalivary glandtumor. |
| spellingShingle | Sedigheh Rahrotaban Faezeh Azmoudeh Seyedeh Mahboubeh Kiyani Fascin expression in pleomorphic adenoma and mucoepidermoid carcinoma Dental Research Journal Benign immunohistochemistry malignant salivary gland tumor. |
| title | Fascin expression in pleomorphic adenoma and mucoepidermoid carcinoma |
| title_full | Fascin expression in pleomorphic adenoma and mucoepidermoid carcinoma |
| title_fullStr | Fascin expression in pleomorphic adenoma and mucoepidermoid carcinoma |
| title_full_unstemmed | Fascin expression in pleomorphic adenoma and mucoepidermoid carcinoma |
| title_short | Fascin expression in pleomorphic adenoma and mucoepidermoid carcinoma |
| title_sort | fascin expression in pleomorphic adenoma and mucoepidermoid carcinoma |
| topic | Benign immunohistochemistry malignant salivary gland tumor. |
| url | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2014;volume=11;issue=3;spage=370;epage=374;aulast=Rahrotaban |
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