Selective increases in inter-individual variability in response to environmental enrichment in female mice
One manifestation of individualization is a progressively differential response of individuals to the non-shared components of the same environment. Individualization has practical implications in the clinical setting, where subtle differences between patients are often decisive for the success of a...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-10-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/35690 |
| _version_ | 1811180428292259840 |
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| author | Julia C Körholz Sara Zocher Anna N Grzyb Benjamin Morisse Alexandra Poetzsch Fanny Ehret Christopher Schmied Gerd Kempermann |
| author_facet | Julia C Körholz Sara Zocher Anna N Grzyb Benjamin Morisse Alexandra Poetzsch Fanny Ehret Christopher Schmied Gerd Kempermann |
| author_sort | Julia C Körholz |
| collection | DOAJ |
| description | One manifestation of individualization is a progressively differential response of individuals to the non-shared components of the same environment. Individualization has practical implications in the clinical setting, where subtle differences between patients are often decisive for the success of an intervention, yet there has been no suitable animal model to study its underlying biological mechanisms. Here we show that enriched environment (ENR) can serve as a model of brain individualization. We kept 40 isogenic female C57BL/6JRj mice for 3 months in ENR and compared these mice to an equally sized group of standard-housed control animals, looking at the effects on a wide range of phenotypes in terms of both means and variances. Although ENR influenced multiple parameters and restructured correlation patterns between them, it only increased differences among individuals in traits related to brain and behavior (adult hippocampal neurogenesis, motor cortex thickness, open field and object exploration), in agreement with the hypothesis of a specific activity-dependent development of brain individuality. |
| first_indexed | 2024-04-11T09:02:58Z |
| format | Article |
| id | doaj.art-9aff87024efc4e0bbb079e1d56eb5347 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:02:58Z |
| publishDate | 2018-10-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-9aff87024efc4e0bbb079e1d56eb53472022-12-22T04:32:43ZengeLife Sciences Publications LtdeLife2050-084X2018-10-01710.7554/eLife.35690Selective increases in inter-individual variability in response to environmental enrichment in female miceJulia C Körholz0Sara Zocher1Anna N Grzyb2Benjamin Morisse3Alexandra Poetzsch4Fanny Ehret5Christopher Schmied6Gerd Kempermann7https://orcid.org/0000-0002-5304-4061German Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD – Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, GermanyGerman Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD – Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, GermanyGerman Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD – Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, GermanyGerman Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD – Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, GermanyGerman Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD – Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, GermanyGerman Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD – Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, GermanyGerman Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD – Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, GermanyGerman Center for Neurodegenerative Diseases (DZNE) Dresden, Dresden, Germany; CRTD – Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, GermanyOne manifestation of individualization is a progressively differential response of individuals to the non-shared components of the same environment. Individualization has practical implications in the clinical setting, where subtle differences between patients are often decisive for the success of an intervention, yet there has been no suitable animal model to study its underlying biological mechanisms. Here we show that enriched environment (ENR) can serve as a model of brain individualization. We kept 40 isogenic female C57BL/6JRj mice for 3 months in ENR and compared these mice to an equally sized group of standard-housed control animals, looking at the effects on a wide range of phenotypes in terms of both means and variances. Although ENR influenced multiple parameters and restructured correlation patterns between them, it only increased differences among individuals in traits related to brain and behavior (adult hippocampal neurogenesis, motor cortex thickness, open field and object exploration), in agreement with the hypothesis of a specific activity-dependent development of brain individuality.https://elifesciences.org/articles/35690Enriched environmentAdult neurogenesisplasticityhippocampusbehaviorvariance |
| spellingShingle | Julia C Körholz Sara Zocher Anna N Grzyb Benjamin Morisse Alexandra Poetzsch Fanny Ehret Christopher Schmied Gerd Kempermann Selective increases in inter-individual variability in response to environmental enrichment in female mice eLife Enriched environment Adult neurogenesis plasticity hippocampus behavior variance |
| title | Selective increases in inter-individual variability in response to environmental enrichment in female mice |
| title_full | Selective increases in inter-individual variability in response to environmental enrichment in female mice |
| title_fullStr | Selective increases in inter-individual variability in response to environmental enrichment in female mice |
| title_full_unstemmed | Selective increases in inter-individual variability in response to environmental enrichment in female mice |
| title_short | Selective increases in inter-individual variability in response to environmental enrichment in female mice |
| title_sort | selective increases in inter individual variability in response to environmental enrichment in female mice |
| topic | Enriched environment Adult neurogenesis plasticity hippocampus behavior variance |
| url | https://elifesciences.org/articles/35690 |
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