Hydrogels based on chemically modified poly(vinyl alcohol) (PVA-GMA) and PVA-GMA/chondroitin sulfate: Preparation and characterization
This work reports the preparation of hydrogels based on PVA-GMA, PVA-GMA is poly(vinyl alcohol) (PVA) functionalized with vinyl groups from glycidyl methacrylate (GMA), and on PVA-GMA with different content of chondroitin sulfate (CS). The degrees of swelling of PVA-GMA and PVA-GMA/CS hydrogels were...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Budapest University of Technology
2012-05-01
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| Series: | eXPRESS Polymer Letters |
| Subjects: | |
| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0003033&mi=cd |
| _version_ | 1818937197345112064 |
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| author | E. C. Muniz E. G. Crispim A. R. Fajardo J. F. Piai E. R. F. Ramos T. U. Nakamura C. V. Nakamura A. F. Rubira |
| author_facet | E. C. Muniz E. G. Crispim A. R. Fajardo J. F. Piai E. R. F. Ramos T. U. Nakamura C. V. Nakamura A. F. Rubira |
| author_sort | E. C. Muniz |
| collection | DOAJ |
| description | This work reports the preparation of hydrogels based on PVA-GMA, PVA-GMA is poly(vinyl alcohol) (PVA) functionalized with vinyl groups from glycidyl methacrylate (GMA), and on PVA-GMA with different content of chondroitin sulfate (CS). The degrees of swelling of PVA-GMA and PVA-GMA/CS hydrogels were evaluated in distilled water and the swelling kinetics was performed in simulated gastric and intestinal fluids (SGF and SIF). PVA-GMA and PVAGMA/CS hydrogels demonstrated to be resistant on SGF and SIF fluids. The elastic modulus, E, of swollen-hydrogels were determined through compressive tests and, according to the obtained results, the hydrogels presented good mechanical properties. At last, the presence of CS enhances the hydrogel cell compatibility as gathered by cytotoxicity assays. It was concluded that the hydrogels prepared through this work presented characteristics that allow them to be used as biomaterial, as a carrier in drug delivery system or to act as scaffolds in tissue engineering as well. |
| first_indexed | 2024-12-20T05:48:08Z |
| format | Article |
| id | doaj.art-9b003e111358492cb46b4f03d6534685 |
| institution | Directory Open Access Journal |
| issn | 1788-618X |
| language | English |
| last_indexed | 2024-12-20T05:48:08Z |
| publishDate | 2012-05-01 |
| publisher | Budapest University of Technology |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj.art-9b003e111358492cb46b4f03d65346852022-12-21T19:51:15ZengBudapest University of TechnologyeXPRESS Polymer Letters1788-618X2012-05-016538339510.3144/expresspolymlett.2012.41Hydrogels based on chemically modified poly(vinyl alcohol) (PVA-GMA) and PVA-GMA/chondroitin sulfate: Preparation and characterizationE. C. MunizE. G. CrispimA. R. FajardoJ. F. PiaiE. R. F. RamosT. U. NakamuraC. V. NakamuraA. F. RubiraThis work reports the preparation of hydrogels based on PVA-GMA, PVA-GMA is poly(vinyl alcohol) (PVA) functionalized with vinyl groups from glycidyl methacrylate (GMA), and on PVA-GMA with different content of chondroitin sulfate (CS). The degrees of swelling of PVA-GMA and PVA-GMA/CS hydrogels were evaluated in distilled water and the swelling kinetics was performed in simulated gastric and intestinal fluids (SGF and SIF). PVA-GMA and PVAGMA/CS hydrogels demonstrated to be resistant on SGF and SIF fluids. The elastic modulus, E, of swollen-hydrogels were determined through compressive tests and, according to the obtained results, the hydrogels presented good mechanical properties. At last, the presence of CS enhances the hydrogel cell compatibility as gathered by cytotoxicity assays. It was concluded that the hydrogels prepared through this work presented characteristics that allow them to be used as biomaterial, as a carrier in drug delivery system or to act as scaffolds in tissue engineering as well.http://www.expresspolymlett.com/letolt.php?file=EPL-0003033&mi=cdPolymer gelsPoly(vinyl alcohol)Chondroitin SulfateHydrogelsDrug Delivery |
| spellingShingle | E. C. Muniz E. G. Crispim A. R. Fajardo J. F. Piai E. R. F. Ramos T. U. Nakamura C. V. Nakamura A. F. Rubira Hydrogels based on chemically modified poly(vinyl alcohol) (PVA-GMA) and PVA-GMA/chondroitin sulfate: Preparation and characterization eXPRESS Polymer Letters Polymer gels Poly(vinyl alcohol) Chondroitin Sulfate Hydrogels Drug Delivery |
| title | Hydrogels based on chemically modified poly(vinyl alcohol) (PVA-GMA) and PVA-GMA/chondroitin sulfate: Preparation and characterization |
| title_full | Hydrogels based on chemically modified poly(vinyl alcohol) (PVA-GMA) and PVA-GMA/chondroitin sulfate: Preparation and characterization |
| title_fullStr | Hydrogels based on chemically modified poly(vinyl alcohol) (PVA-GMA) and PVA-GMA/chondroitin sulfate: Preparation and characterization |
| title_full_unstemmed | Hydrogels based on chemically modified poly(vinyl alcohol) (PVA-GMA) and PVA-GMA/chondroitin sulfate: Preparation and characterization |
| title_short | Hydrogels based on chemically modified poly(vinyl alcohol) (PVA-GMA) and PVA-GMA/chondroitin sulfate: Preparation and characterization |
| title_sort | hydrogels based on chemically modified poly vinyl alcohol pva gma and pva gma chondroitin sulfate preparation and characterization |
| topic | Polymer gels Poly(vinyl alcohol) Chondroitin Sulfate Hydrogels Drug Delivery |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0003033&mi=cd |
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