Mechanical overloading-induced miR-325-3p reduction promoted chondrocyte senescence and exacerbated facet joint degeneration

Mechanical overloading-induced miR-325-3p reduction promoted chondrocyte senescence and exacerbated facet joint degeneration

Abstract Objective Lumbar facet joint (LFJ) degeneration is one of the main causes of low back pain (LBP). Mechanical stress leads to the exacerbation of LFJ degeneration, but the underlying mechanism remains unknown. This study was intended to investigate the mechanism of LFJ degeneration induced b...

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Bibliographic Details
Main Authors: Jinyun Zhao, Chengjun Li, Tian Qin, Yuxin Jin, Rundong He, Yi Sun, Zhide Liu, Tianding Wu, Chunyue Duan, Yong Cao, Jianzhong Hu
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Arthritis Research & Therapy
Subjects:
Lumbar facet joints
Degeneration
Mechanical overloading
MiR-325-3p
Chondrocyte senescence
Online Access:https://doi.org/10.1186/s13075-023-03037-3

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