Stroke–Heart Syndrome: Recent Advances and Challenges
After ischemic stroke, there is a significant burden of cardiovascular complications, both in the acute and chronic phase. Severe adverse cardiac events occur in 10% to 20% of patients within the first few days after stroke and comprise a continuum of cardiac changes ranging from acute myocardial in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.026528 |
| _version_ | 1818022929088118784 |
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| author | Jan F. Scheitz Luciano A. Sposato Jeanette Schulz‐Menger Christian H. Nolte Johannes Backs Matthias Endres |
| author_facet | Jan F. Scheitz Luciano A. Sposato Jeanette Schulz‐Menger Christian H. Nolte Johannes Backs Matthias Endres |
| author_sort | Jan F. Scheitz |
| collection | DOAJ |
| description | After ischemic stroke, there is a significant burden of cardiovascular complications, both in the acute and chronic phase. Severe adverse cardiac events occur in 10% to 20% of patients within the first few days after stroke and comprise a continuum of cardiac changes ranging from acute myocardial injury and coronary syndromes to heart failure or arrhythmia. Recently, the term stroke–heart syndrome was introduced to provide an integrated conceptual framework that summarizes neurocardiogenic mechanisms that lead to these cardiac events after stroke. New findings from experimental and clinical studies have further refined our understanding of the clinical manifestations, pathophysiology, and potential long‐term consequences of the stroke–heart syndrome. Local cerebral and systemic mediators, which mainly involve autonomic dysfunction and increased inflammation, may lead to altered cardiomyocyte metabolism, dysregulation of (tissue‐resident) leukocyte populations, and (micro‐) vascular changes. However, at the individual patient level, it remains challenging to differentiate between comorbid cardiovascular conditions and stroke‐induced heart injury. Therefore, further research activities led by joint teams of basic and clinical researchers with backgrounds in both cardiology and neurology are needed to identify the most relevant therapeutic targets that can be tested in clinical trials. |
| first_indexed | 2024-12-10T03:36:14Z |
| format | Article |
| id | doaj.art-9b03c5b01f91436ea1fd41f45d738bc9 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-10T03:36:14Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-9b03c5b01f91436ea1fd41f45d738bc92022-12-22T02:03:42ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-09-01111710.1161/JAHA.122.026528Stroke–Heart Syndrome: Recent Advances and ChallengesJan F. Scheitz0Luciano A. Sposato1Jeanette Schulz‐Menger2Christian H. Nolte3Johannes Backs4Matthias Endres5Department of Neurology With Experimental Neurology Charité‐Universitätsmedizin Berlin Berlin GermanyWorld Stroke Organization Brain & Heart Task ForceWorking Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a Joint Cooperation Between the Charité–Universitätsmedizin Berlin, Department of Internal Medicine and Cardiology and the Max‐Delbrueck Center for Molecular Medicine DZHK (German Centre for Cardiovascular Research), Partner Site Berlin Berlin GermanyDepartment of Neurology With Experimental Neurology Charité‐Universitätsmedizin Berlin Berlin GermanyInstitute of Experimental Cardiology Heidelberg University Heidelberg GermanyDepartment of Neurology With Experimental Neurology Charité‐Universitätsmedizin Berlin Berlin GermanyAfter ischemic stroke, there is a significant burden of cardiovascular complications, both in the acute and chronic phase. Severe adverse cardiac events occur in 10% to 20% of patients within the first few days after stroke and comprise a continuum of cardiac changes ranging from acute myocardial injury and coronary syndromes to heart failure or arrhythmia. Recently, the term stroke–heart syndrome was introduced to provide an integrated conceptual framework that summarizes neurocardiogenic mechanisms that lead to these cardiac events after stroke. New findings from experimental and clinical studies have further refined our understanding of the clinical manifestations, pathophysiology, and potential long‐term consequences of the stroke–heart syndrome. Local cerebral and systemic mediators, which mainly involve autonomic dysfunction and increased inflammation, may lead to altered cardiomyocyte metabolism, dysregulation of (tissue‐resident) leukocyte populations, and (micro‐) vascular changes. However, at the individual patient level, it remains challenging to differentiate between comorbid cardiovascular conditions and stroke‐induced heart injury. Therefore, further research activities led by joint teams of basic and clinical researchers with backgrounds in both cardiology and neurology are needed to identify the most relevant therapeutic targets that can be tested in clinical trials.https://www.ahajournals.org/doi/10.1161/JAHA.122.026528brain–heart axisheartinflammationoutcomesstroke |
| spellingShingle | Jan F. Scheitz Luciano A. Sposato Jeanette Schulz‐Menger Christian H. Nolte Johannes Backs Matthias Endres Stroke–Heart Syndrome: Recent Advances and Challenges Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease brain–heart axis heart inflammation outcomes stroke |
| title | Stroke–Heart Syndrome: Recent Advances and Challenges |
| title_full | Stroke–Heart Syndrome: Recent Advances and Challenges |
| title_fullStr | Stroke–Heart Syndrome: Recent Advances and Challenges |
| title_full_unstemmed | Stroke–Heart Syndrome: Recent Advances and Challenges |
| title_short | Stroke–Heart Syndrome: Recent Advances and Challenges |
| title_sort | stroke heart syndrome recent advances and challenges |
| topic | brain–heart axis heart inflammation outcomes stroke |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.122.026528 |
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