Hope for bone regeneration: The versatility of iron oxide nanoparticles
Abstract: Although bone tissue has the ability to heal itself, beyond a certain point, bone defects cannot rebuild themselves, and the challenge is how to promote bone tissue regeneration. Iron oxide nanoparticles (IONPs) are a magnetic material because of their excellent properties, which enable th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.937803/full |
| _version_ | 1828757624339824640 |
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| author | Nan Wang Yimin Xie Zhipeng Xi Zehua Mi Rongrong Deng Xiyu Liu Ran Kang Ran Kang Xin Liu Xin Liu |
| author_facet | Nan Wang Yimin Xie Zhipeng Xi Zehua Mi Rongrong Deng Xiyu Liu Ran Kang Ran Kang Xin Liu Xin Liu |
| author_sort | Nan Wang |
| collection | DOAJ |
| description | Abstract: Although bone tissue has the ability to heal itself, beyond a certain point, bone defects cannot rebuild themselves, and the challenge is how to promote bone tissue regeneration. Iron oxide nanoparticles (IONPs) are a magnetic material because of their excellent properties, which enable them to play an active role in bone regeneration. This paper reviews the application of IONPs in bone tissue regeneration in recent years, and outlines the mechanisms of IONPs in bone tissue regeneration in detail based on the physicochemical properties, structural characteristics and safety of IONPs. In addition, a bibliometric approach has been used to analyze the hot spots and trends in the field in order to identify future directions. The results demonstrate that IONPs are increasingly being investigated in bone regeneration, from the initial use as magnetic resonance imaging (MRI) contrast agents to later drug delivery vehicles, cell labeling, and now in combination with stem cells (SCs) composite scaffolds. In conclusion, based on the current research and development trends, it is more inclined to be used in bone tissue engineering, scaffolds, and composite scaffolds. |
| first_indexed | 2024-12-11T00:29:47Z |
| format | Article |
| id | doaj.art-9b059f47977044679397afea15d9dc27 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-11T00:29:47Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-9b059f47977044679397afea15d9dc272022-12-22T01:27:24ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-08-011010.3389/fbioe.2022.937803937803Hope for bone regeneration: The versatility of iron oxide nanoparticlesNan Wang0Yimin Xie1Zhipeng Xi2Zehua Mi3Rongrong Deng4Xiyu Liu5Ran Kang6Ran Kang7Xin Liu8Xin Liu9Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaHospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing, ChinaAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Orthopedics, Nanjing Lishui Hospital of Traditional Chinese Medicine, Nanjing, ChinaAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Orthopedics, Nanjing Lishui Hospital of Traditional Chinese Medicine, Nanjing, ChinaAbstract: Although bone tissue has the ability to heal itself, beyond a certain point, bone defects cannot rebuild themselves, and the challenge is how to promote bone tissue regeneration. Iron oxide nanoparticles (IONPs) are a magnetic material because of their excellent properties, which enable them to play an active role in bone regeneration. This paper reviews the application of IONPs in bone tissue regeneration in recent years, and outlines the mechanisms of IONPs in bone tissue regeneration in detail based on the physicochemical properties, structural characteristics and safety of IONPs. In addition, a bibliometric approach has been used to analyze the hot spots and trends in the field in order to identify future directions. The results demonstrate that IONPs are increasingly being investigated in bone regeneration, from the initial use as magnetic resonance imaging (MRI) contrast agents to later drug delivery vehicles, cell labeling, and now in combination with stem cells (SCs) composite scaffolds. In conclusion, based on the current research and development trends, it is more inclined to be used in bone tissue engineering, scaffolds, and composite scaffolds.https://www.frontiersin.org/articles/10.3389/fbioe.2022.937803/fulliron oxide nanoparticlestissue engineeringbone regenerationscaffoldsstem cells |
| spellingShingle | Nan Wang Yimin Xie Zhipeng Xi Zehua Mi Rongrong Deng Xiyu Liu Ran Kang Ran Kang Xin Liu Xin Liu Hope for bone regeneration: The versatility of iron oxide nanoparticles Frontiers in Bioengineering and Biotechnology iron oxide nanoparticles tissue engineering bone regeneration scaffolds stem cells |
| title | Hope for bone regeneration: The versatility of iron oxide nanoparticles |
| title_full | Hope for bone regeneration: The versatility of iron oxide nanoparticles |
| title_fullStr | Hope for bone regeneration: The versatility of iron oxide nanoparticles |
| title_full_unstemmed | Hope for bone regeneration: The versatility of iron oxide nanoparticles |
| title_short | Hope for bone regeneration: The versatility of iron oxide nanoparticles |
| title_sort | hope for bone regeneration the versatility of iron oxide nanoparticles |
| topic | iron oxide nanoparticles tissue engineering bone regeneration scaffolds stem cells |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.937803/full |
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