An atypical presentation of granulomatosis with polyangiitis: A case report

An atypical presentation of granulomatosis with polyangiitis: A case report

Granulomatosis with polyangiitis (GPA) is a systemic vasculitis that is associated with antineutrophil cytoplasmic antibodies (c-ANCA). It classically presents with sinonasal, pulmonary and renal involvement. We are presenting a case of a 32-year-old male who presented with septal perforation, crust...

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Bibliographic Details
Main Authors: Umar Maqbool, MBBS, Abdullah Maqbool, MBBS, Ayesha Maqbool, MBBS, Ahsan Qadeer, MBBS, Muhammad Fayzan Mehmood, MBBS, Muaz Loon, MBBS
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Radiology Case Reports
Subjects:
Granulomatosis with polyangiitis
Antineutrophil cytoplasmic antibodies
Sinonasal polyposis
Systemic vasculitis
Sinusitis
Online Access:http://www.sciencedirect.com/science/article/pii/S1930043323001954
Description
Summary:Granulomatosis with polyangiitis (GPA) is a systemic vasculitis that is associated with antineutrophil cytoplasmic antibodies (c-ANCA). It classically presents with sinonasal, pulmonary and renal involvement. We are presenting a case of a 32-year-old male who presented with septal perforation, crusting and nasal obstruction. He had been operated on twice for sinonasal polyposis. Relevant investigations revealed that he was actually suffering from GPA. The patient was started on remission induction therapy. A combination of methotrexate and prednisolone was started with a 2-weekly follow-up. The patient had experienced his symptoms for 2 years before presentation. This case highlights the importance of correlating ENT and pulmonary symptoms to reach the correct diagnosis.
ISSN:1930-0433

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