Species tropism of HIV-1 modulated by viral accessory proteins
Human immunodeficiency virus type 1 (HIV-1) is tropic and pathogenic only for humans, and does not replicate in macaque monkeys routinely used for experimental infections. This specially narrow host range (species tropism) has impeded much the progress of HIV-1/acquired immunodeficiency syndrome (AI...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-07-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00267/full |
| _version_ | 1811342249261268992 |
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| author | Masako eNomaguchi Naoya eDoi Yui eMatsumoto Yosuke eSakai Sachi eFujiwara Akio eAdachi |
| author_facet | Masako eNomaguchi Naoya eDoi Yui eMatsumoto Yosuke eSakai Sachi eFujiwara Akio eAdachi |
| author_sort | Masako eNomaguchi |
| collection | DOAJ |
| description | Human immunodeficiency virus type 1 (HIV-1) is tropic and pathogenic only for humans, and does not replicate in macaque monkeys routinely used for experimental infections. This specially narrow host range (species tropism) has impeded much the progress of HIV-1/acquired immunodeficiency syndrome (AIDS) basic research. Extensive studies on the underlying mechanism have revealed that Vif, one of viral accessory proteins, is critical for the HIV-1 species tropism in addition to Gag capsid protein. Another auxiliary protein Vpu also has been demonstrated to affect this HIV-1 property. In this review, we focus on functional interactions of these HIV-1 proteins and species specific-restriction factors. In addition, we describe an evolutional viewpoint that is relevant to the species tropism of HIV-1 controlled by the accessory proteins. |
| first_indexed | 2024-04-13T19:08:19Z |
| format | Article |
| id | doaj.art-9b09d7a134ca46aea43588b81e8a2ea0 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T19:08:19Z |
| publishDate | 2012-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-9b09d7a134ca46aea43588b81e8a2ea02022-12-22T02:33:55ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2012-07-01310.3389/fmicb.2012.0026732291Species tropism of HIV-1 modulated by viral accessory proteinsMasako eNomaguchi0Naoya eDoi1Yui eMatsumoto2Yosuke eSakai3Sachi eFujiwara4Akio eAdachi5The University of Tokushima Graduate SchoolThe University of Tokushima Graduate SchoolThe University of Tokushima Graduate SchoolThe University of Tokushima Graduate SchoolThe University of Tokushima Graduate SchoolThe University of Tokushima Graduate SchoolHuman immunodeficiency virus type 1 (HIV-1) is tropic and pathogenic only for humans, and does not replicate in macaque monkeys routinely used for experimental infections. This specially narrow host range (species tropism) has impeded much the progress of HIV-1/acquired immunodeficiency syndrome (AIDS) basic research. Extensive studies on the underlying mechanism have revealed that Vif, one of viral accessory proteins, is critical for the HIV-1 species tropism in addition to Gag capsid protein. Another auxiliary protein Vpu also has been demonstrated to affect this HIV-1 property. In this review, we focus on functional interactions of these HIV-1 proteins and species specific-restriction factors. In addition, we describe an evolutional viewpoint that is relevant to the species tropism of HIV-1 controlled by the accessory proteins.http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00267/fullHIV-1VifVpuspecies tropismaccessory protein |
| spellingShingle | Masako eNomaguchi Naoya eDoi Yui eMatsumoto Yosuke eSakai Sachi eFujiwara Akio eAdachi Species tropism of HIV-1 modulated by viral accessory proteins Frontiers in Microbiology HIV-1 Vif Vpu species tropism accessory protein |
| title | Species tropism of HIV-1 modulated by viral accessory proteins |
| title_full | Species tropism of HIV-1 modulated by viral accessory proteins |
| title_fullStr | Species tropism of HIV-1 modulated by viral accessory proteins |
| title_full_unstemmed | Species tropism of HIV-1 modulated by viral accessory proteins |
| title_short | Species tropism of HIV-1 modulated by viral accessory proteins |
| title_sort | species tropism of hiv 1 modulated by viral accessory proteins |
| topic | HIV-1 Vif Vpu species tropism accessory protein |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00267/full |
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