ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE
Hormone-receptor positive breast cancer is the most common molecular subtype and represents 60–75 % of all breast cancers (BC). The presence of specific molecular targets such as the estrogen/progesterone receptor determines the use of hormone therapy for patients with this subtype. Tamoxifen, a sel...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2020-09-01
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| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/1540 |
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| author | D. B. Erdyneeva N. N. Babyshkina T. A. Dronova S. V. Vtorushin E. M. Slonimskaya V. N. Stegniy N. V. Cherdyntseva |
| author_facet | D. B. Erdyneeva N. N. Babyshkina T. A. Dronova S. V. Vtorushin E. M. Slonimskaya V. N. Stegniy N. V. Cherdyntseva |
| author_sort | D. B. Erdyneeva |
| collection | DOAJ |
| description | Hormone-receptor positive breast cancer is the most common molecular subtype and represents 60–75 % of all breast cancers (BC). The presence of specific molecular targets such as the estrogen/progesterone receptor determines the use of hormone therapy for patients with this subtype. Tamoxifen, a selective estrogen receptor modulator, remains the first adjuvant treatment choice for the hormone-receptor positive BC patients. However, tamoxifen resistance is the major limitation of its efficacy. In this regard, the study of drug resistance mechanisms as well as search for biological prognostic markers of tamoxifen efficacy is very important. Cyclin D1 is a representative of the regulatory protein family, which plays a central role in the cell cycle regulation. The data on the association between cyclin D1 and estrogen-dependent signaling as well as the characteristics of CCND1 gene and its most studied polymorphic loci, were presented. The prognostic significance of cyclin D1 in hormone-receptor positive BC receptor-positive breast cancer was described. The experimental and clinical studies data on the association between the cyclin D1 expression level and tamoxifen efficacy are analyzed. Current approaches to overcoming hormone resistance based on cyclin D1 studies were considered. |
| first_indexed | 2024-04-10T01:52:24Z |
| format | Article |
| id | doaj.art-9b0a62a156e847f2895d31c20ae96a1d |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:52:24Z |
| publishDate | 2020-09-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-9b0a62a156e847f2895d31c20ae96a1d2023-03-13T09:05:53ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682020-09-0119413814510.21294/1814-4861-2020-19-4-138-145777ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCED. B. Erdyneeva0N. N. Babyshkina1T. A. Dronova2S. V. Vtorushin3E. M. Slonimskaya4V. N. Stegniy5N. V. Cherdyntseva6Сибирский государственный медицинский университет Министерства здравоохранения Российской ФедерацииНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук; Национальный исследовательский Томский государственный университетНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук; Национальный исследовательский Томский государственный университетСибирский государственный медицинский университет Министерства здравоохранения Российской Федерации; Научно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наукСанкт-Петербургский государственный университетНациональный исследовательский Томский государственный университетСибирский государственный медицинский университет Министерства здравоохранения Российской Федерации; Научно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук; Национальный исследовательский Томский государственный университетHormone-receptor positive breast cancer is the most common molecular subtype and represents 60–75 % of all breast cancers (BC). The presence of specific molecular targets such as the estrogen/progesterone receptor determines the use of hormone therapy for patients with this subtype. Tamoxifen, a selective estrogen receptor modulator, remains the first adjuvant treatment choice for the hormone-receptor positive BC patients. However, tamoxifen resistance is the major limitation of its efficacy. In this regard, the study of drug resistance mechanisms as well as search for biological prognostic markers of tamoxifen efficacy is very important. Cyclin D1 is a representative of the regulatory protein family, which plays a central role in the cell cycle regulation. The data on the association between cyclin D1 and estrogen-dependent signaling as well as the characteristics of CCND1 gene and its most studied polymorphic loci, were presented. The prognostic significance of cyclin D1 in hormone-receptor positive BC receptor-positive breast cancer was described. The experimental and clinical studies data on the association between the cyclin D1 expression level and tamoxifen efficacy are analyzed. Current approaches to overcoming hormone resistance based on cyclin D1 studies were considered.https://www.siboncoj.ru/jour/article/view/1540рецептор-позитивный рак молочной железыциклин d1тамоксифенмеханизмы резистентности |
| spellingShingle | D. B. Erdyneeva N. N. Babyshkina T. A. Dronova S. V. Vtorushin E. M. Slonimskaya V. N. Stegniy N. V. Cherdyntseva ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE Сибирский онкологический журнал рецептор-позитивный рак молочной железы циклин d1 тамоксифен механизмы резистентности |
| title | ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE |
| title_full | ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE |
| title_fullStr | ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE |
| title_full_unstemmed | ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE |
| title_short | ROLE OF CYCLIN D1 IN THE MECHANISMS OF TAMOXIFEN RESISTANCE |
| title_sort | role of cyclin d1 in the mechanisms of tamoxifen resistance |
| topic | рецептор-позитивный рак молочной железы циклин d1 тамоксифен механизмы резистентности |
| url | https://www.siboncoj.ru/jour/article/view/1540 |
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