Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy
Abstract The prevalence and impact of imaging findings detected during screening procedures in patients undergoing transcranial MR-guided Focused Ultrasound (tcMRgFUS) thalamotomy for functional neurological disorders has not been assessed yet. This study included 90 patients who fully completed cli...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-82271-8 |
| _version_ | 1828978070124494848 |
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| author | Cesare Gagliardo Roberto Cannella Giuseppe Filorizzo Patrizia Toia Giuseppe Salvaggio Giorgio Collura Antonia Pignolo Rosario Maugeri Alessandro Napoli Marco D’amelio Tommaso Vincenzo Bartolotta Maurizio Marrale Gerardo Domenico Iacopino Carlo Catalano Massimo Midiri |
| author_facet | Cesare Gagliardo Roberto Cannella Giuseppe Filorizzo Patrizia Toia Giuseppe Salvaggio Giorgio Collura Antonia Pignolo Rosario Maugeri Alessandro Napoli Marco D’amelio Tommaso Vincenzo Bartolotta Maurizio Marrale Gerardo Domenico Iacopino Carlo Catalano Massimo Midiri |
| author_sort | Cesare Gagliardo |
| collection | DOAJ |
| description | Abstract The prevalence and impact of imaging findings detected during screening procedures in patients undergoing transcranial MR-guided Focused Ultrasound (tcMRgFUS) thalamotomy for functional neurological disorders has not been assessed yet. This study included 90 patients who fully completed clinical and neuroradiological screenings for tcMRgFUS in a single-center. The presence and location of preoperative imaging findings that could impact the treatment were recorded and classified in three different groups according to their relevance for the eligibility and treatment planning. Furthermore, tcMRgFUS treatments were reviewed to evaluate the number of transducer elements turned off after marking as no pass regions the depicted imaging finding. A total of 146 preoperative imaging findings in 79 (87.8%) patients were detected in the screening population, with a significant correlation with patients’ age (rho = 483, p < 0.001). With regard of the group classification, 119 (81.5%), 26 (17.8%) were classified as group 1 or 2, respectively. One patient had group 3 finding and was considered ineligible. No complications related to the preoperative imaging findings occurred in treated patients. Preoperative neuroradiological findings are frequent in candidates to tcMRgFUS and their identification may require the placement of additional no-pass regions to prevent harmful non-targeted heating. |
| first_indexed | 2024-12-14T15:10:05Z |
| format | Article |
| id | doaj.art-9b0a9121d3a0488b8605ff50ef68be9f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T15:10:05Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9b0a9121d3a0488b8605ff50ef68be9f2022-12-21T22:56:35ZengNature PortfolioScientific Reports2045-23222021-01-0111111110.1038/s41598-021-82271-8Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomyCesare Gagliardo0Roberto Cannella1Giuseppe Filorizzo2Patrizia Toia3Giuseppe Salvaggio4Giorgio Collura5Antonia Pignolo6Rosario Maugeri7Alessandro Napoli8Marco D’amelio9Tommaso Vincenzo Bartolotta10Maurizio Marrale11Gerardo Domenico Iacopino12Carlo Catalano13Massimo Midiri14Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of PalermoDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, University of PalermoDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, University of PalermoDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, University of PalermoDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, University of PalermoDepartment of Physics and Chemistry, University of PalermoDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, University of PalermoDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, University of PalermoDepartment of Radiological, Oncological and Anatomopathological Sciences, ‘Sapienza’ University of RomeDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, University of PalermoDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, University of PalermoDepartment of Physics and Chemistry, University of PalermoDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, University of PalermoDepartment of Radiological, Oncological and Anatomopathological Sciences, ‘Sapienza’ University of RomeDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, University of PalermoAbstract The prevalence and impact of imaging findings detected during screening procedures in patients undergoing transcranial MR-guided Focused Ultrasound (tcMRgFUS) thalamotomy for functional neurological disorders has not been assessed yet. This study included 90 patients who fully completed clinical and neuroradiological screenings for tcMRgFUS in a single-center. The presence and location of preoperative imaging findings that could impact the treatment were recorded and classified in three different groups according to their relevance for the eligibility and treatment planning. Furthermore, tcMRgFUS treatments were reviewed to evaluate the number of transducer elements turned off after marking as no pass regions the depicted imaging finding. A total of 146 preoperative imaging findings in 79 (87.8%) patients were detected in the screening population, with a significant correlation with patients’ age (rho = 483, p < 0.001). With regard of the group classification, 119 (81.5%), 26 (17.8%) were classified as group 1 or 2, respectively. One patient had group 3 finding and was considered ineligible. No complications related to the preoperative imaging findings occurred in treated patients. Preoperative neuroradiological findings are frequent in candidates to tcMRgFUS and their identification may require the placement of additional no-pass regions to prevent harmful non-targeted heating.https://doi.org/10.1038/s41598-021-82271-8 |
| spellingShingle | Cesare Gagliardo Roberto Cannella Giuseppe Filorizzo Patrizia Toia Giuseppe Salvaggio Giorgio Collura Antonia Pignolo Rosario Maugeri Alessandro Napoli Marco D’amelio Tommaso Vincenzo Bartolotta Maurizio Marrale Gerardo Domenico Iacopino Carlo Catalano Massimo Midiri Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy Scientific Reports |
| title | Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy |
| title_full | Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy |
| title_fullStr | Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy |
| title_full_unstemmed | Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy |
| title_short | Preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy |
| title_sort | preoperative imaging findings in patients undergoing transcranial magnetic resonance imaging guided focused ultrasound thalamotomy |
| url | https://doi.org/10.1038/s41598-021-82271-8 |
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