Molecular insight into pentraxin-3: Update advances in innate immunity, inflammation, tissue remodeling, diseases, and drug role
Pentraxin-3 (PTX3) is the prototype of the long pentraxin subfamily, an acute-phase protein consisting of a C-terminal pentraxin domain and a unique N-terminal domain. PTX3 was initially isolated from human umbilical vein endothelial cells and human FS-4 fibroblasts. It was subsequently found to be...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222011726 |
| _version_ | 1811308641313095680 |
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| author | Hao Zhang Ruixuan Wang Zeyu Wang Wantao Wu Nan Zhang Longbo Zhang Jason Hu Peng Luo Jian Zhang Zaoqu Liu Songshan Feng Yun Peng Zhengzheng Liu Quan Cheng |
| author_facet | Hao Zhang Ruixuan Wang Zeyu Wang Wantao Wu Nan Zhang Longbo Zhang Jason Hu Peng Luo Jian Zhang Zaoqu Liu Songshan Feng Yun Peng Zhengzheng Liu Quan Cheng |
| author_sort | Hao Zhang |
| collection | DOAJ |
| description | Pentraxin-3 (PTX3) is the prototype of the long pentraxin subfamily, an acute-phase protein consisting of a C-terminal pentraxin domain and a unique N-terminal domain. PTX3 was initially isolated from human umbilical vein endothelial cells and human FS-4 fibroblasts. It was subsequently found to be also produced by synoviocytes, chondrocytes, osteoblasts, smooth muscle cells, myeloid dendritic cells, epithelial cells, and tumor cells. Various modulatory factors, such as miRNAs, cytokines, drugs, and hypoxic conditions, could regulate the expression level of PTX3. PTX3 is essential in regulating innate immunity, inflammation, angiogenesis, and tissue remodeling. Besides, PTX3 may play dual (pro-tumor and anti-tumor) roles in oncogenesis. PTX3 is involved in the occurrence and development of many non-cancerous diseases, including COVID-19, and might be a potential biomarker indicating the prognosis, activity,and severity of diseases. In this review, we summarize and discuss the potential roles of PTX3 in the oncogenesis and pathogenesis of non-cancerous diseases and potential targeted therapies based on PTX3. |
| first_indexed | 2024-04-13T09:26:54Z |
| format | Article |
| id | doaj.art-9b0b238900604e07badc8badefc775be |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-13T09:26:54Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-9b0b238900604e07badc8badefc775be2022-12-22T02:52:24ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-12-01156113783Molecular insight into pentraxin-3: Update advances in innate immunity, inflammation, tissue remodeling, diseases, and drug roleHao Zhang0Ruixuan Wang1Zeyu Wang2Wantao Wu3Nan Zhang4Longbo Zhang5Jason Hu6Peng Luo7Jian Zhang8Zaoqu Liu9Songshan Feng10Yun Peng11Zhengzheng Liu12Quan Cheng13Department of Neurosurgery, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, China; Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, ChinaDepartment of Oncology, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, ChinaDepartment of Oncology, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, China; One-third Lab, College of Bioinformatics Science and Technology, Harbin Medical University, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, China; Department of Neurosurgery, and Department of Cellular & Molecular Physiology,Yale University School of Medicine, USA; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, ChinaDepartment of Neonatology, Yale University School of Medicine, USADepartment of Oncology, Zhujiang Hospital, Southern Medical University, ChinaDepartment of Oncology, Zhujiang Hospital, Southern Medical University, ChinaDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, ChinaDepartment of Geriatrics, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, ChinaDepartment of Oncology, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, China; Corresponding author at: Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.Department of Neurosurgery, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, China; Corresponding author at: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.Pentraxin-3 (PTX3) is the prototype of the long pentraxin subfamily, an acute-phase protein consisting of a C-terminal pentraxin domain and a unique N-terminal domain. PTX3 was initially isolated from human umbilical vein endothelial cells and human FS-4 fibroblasts. It was subsequently found to be also produced by synoviocytes, chondrocytes, osteoblasts, smooth muscle cells, myeloid dendritic cells, epithelial cells, and tumor cells. Various modulatory factors, such as miRNAs, cytokines, drugs, and hypoxic conditions, could regulate the expression level of PTX3. PTX3 is essential in regulating innate immunity, inflammation, angiogenesis, and tissue remodeling. Besides, PTX3 may play dual (pro-tumor and anti-tumor) roles in oncogenesis. PTX3 is involved in the occurrence and development of many non-cancerous diseases, including COVID-19, and might be a potential biomarker indicating the prognosis, activity,and severity of diseases. In this review, we summarize and discuss the potential roles of PTX3 in the oncogenesis and pathogenesis of non-cancerous diseases and potential targeted therapies based on PTX3.http://www.sciencedirect.com/science/article/pii/S0753332222011726PTX3Innate immunityTissue remodelingOncogenesisCOVID-19 |
| spellingShingle | Hao Zhang Ruixuan Wang Zeyu Wang Wantao Wu Nan Zhang Longbo Zhang Jason Hu Peng Luo Jian Zhang Zaoqu Liu Songshan Feng Yun Peng Zhengzheng Liu Quan Cheng Molecular insight into pentraxin-3: Update advances in innate immunity, inflammation, tissue remodeling, diseases, and drug role Biomedicine & Pharmacotherapy PTX3 Innate immunity Tissue remodeling Oncogenesis COVID-19 |
| title | Molecular insight into pentraxin-3: Update advances in innate immunity, inflammation, tissue remodeling, diseases, and drug role |
| title_full | Molecular insight into pentraxin-3: Update advances in innate immunity, inflammation, tissue remodeling, diseases, and drug role |
| title_fullStr | Molecular insight into pentraxin-3: Update advances in innate immunity, inflammation, tissue remodeling, diseases, and drug role |
| title_full_unstemmed | Molecular insight into pentraxin-3: Update advances in innate immunity, inflammation, tissue remodeling, diseases, and drug role |
| title_short | Molecular insight into pentraxin-3: Update advances in innate immunity, inflammation, tissue remodeling, diseases, and drug role |
| title_sort | molecular insight into pentraxin 3 update advances in innate immunity inflammation tissue remodeling diseases and drug role |
| topic | PTX3 Innate immunity Tissue remodeling Oncogenesis COVID-19 |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222011726 |
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