Metformin alleviates bone loss in ovariectomized mice through inhibition of autophagy of osteoclast precursors mediated by E2F1

Metformin alleviates bone loss in ovariectomized mice through inhibition of autophagy of osteoclast precursors mediated by E2F1

Abstract Background Postmenopausal bone loss, mainly caused by excessive bone resorption mediated by osteoclasts, has become a global public health burden. Metformin, a hypoglycemic drug, has been reported to have beneficial effects on maintaining bone health. However, the role and underlying mechan...

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Bibliographic Details
Main Authors: Xudong Xie, Liangcong Hu, Bobin Mi, Hang Xue, Yiqiang Hu, Adriana C. Panayi, Yori Endo, Lang Chen, Chenchen Yan, Ze Lin, Hui Li, Wu Zhou, Guohui Liu
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Cell Communication and Signaling
Subjects:
Metformin
Osteoclast precursors
Bone loss
Autophagy
E2F1
BECN1
Online Access:https://doi.org/10.1186/s12964-022-00966-5

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