The melanocortin receptors and their accessory proteins
The five melanocortin receptors named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behaviour as well as exocrine function. Since their identification almost 20 years ago much has been learnt about these receptors. As well as in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-02-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00009/full |
| _version_ | 1819018128808476672 |
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| author | Shwetha eRamachandrappa Rebecca eGorrigan Adrian eClark Li eChan |
| author_facet | Shwetha eRamachandrappa Rebecca eGorrigan Adrian eClark Li eChan |
| author_sort | Shwetha eRamachandrappa |
| collection | DOAJ |
| description | The five melanocortin receptors named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behaviour as well as exocrine function. Since their identification almost 20 years ago much has been learnt about these receptors. As well as interacting with their endogenous ligands the melanocortin peptides, there is now a growing list of important peptides that can modulate the way these receptors signal, acting as agonists, antagonists and inverse agonists. The discovery of MRAPs as a novel accessory factor to the melanocortin receptors provides further insight into the regulation of these important GPCRs. |
| first_indexed | 2024-12-21T03:14:30Z |
| format | Article |
| id | doaj.art-9b0c8e883f5a4b9ab1a0265c0678b2ce |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-21T03:14:30Z |
| publishDate | 2013-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-9b0c8e883f5a4b9ab1a0265c0678b2ce2022-12-21T19:17:53ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922013-02-01410.3389/fendo.2013.0000940048The melanocortin receptors and their accessory proteinsShwetha eRamachandrappa0Rebecca eGorrigan1Adrian eClark2Li eChan3Queen Mary University of LondonQueen Mary University of LondonQueen Mary University of LondonQueen Mary University of LondonThe five melanocortin receptors named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behaviour as well as exocrine function. Since their identification almost 20 years ago much has been learnt about these receptors. As well as interacting with their endogenous ligands the melanocortin peptides, there is now a growing list of important peptides that can modulate the way these receptors signal, acting as agonists, antagonists and inverse agonists. The discovery of MRAPs as a novel accessory factor to the melanocortin receptors provides further insight into the regulation of these important GPCRs.http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00009/fullAdrenal CortexObesityaccessory proteinsmelanocortin receptorsFamilial Glucocorticoid Deficiency |
| spellingShingle | Shwetha eRamachandrappa Rebecca eGorrigan Adrian eClark Li eChan The melanocortin receptors and their accessory proteins Frontiers in Endocrinology Adrenal Cortex Obesity accessory proteins melanocortin receptors Familial Glucocorticoid Deficiency |
| title | The melanocortin receptors and their accessory proteins |
| title_full | The melanocortin receptors and their accessory proteins |
| title_fullStr | The melanocortin receptors and their accessory proteins |
| title_full_unstemmed | The melanocortin receptors and their accessory proteins |
| title_short | The melanocortin receptors and their accessory proteins |
| title_sort | melanocortin receptors and their accessory proteins |
| topic | Adrenal Cortex Obesity accessory proteins melanocortin receptors Familial Glucocorticoid Deficiency |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00009/full |
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