FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models

FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models

Abstract The tumour microenvironment is infiltrated by immunosuppressive cells, such as regulatory T cells (Tregs), which contribute to tumour escape and impede immunotherapy outcomes. Soluble fibrinogen-like protein 2 (sFGL2), a Treg effector protein, inhibits immune cell populations, via receptors...

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Bibliographic Details
Main Authors: Kristianne J. C. Galpin, Galaxia M. Rodriguez, Vincent Maranda, David P. Cook, Elizabeth Macdonald, Humaira Murshed, Shan Zhao, Curtis W. McCloskey, Andrzej Chruscinski, Gary A. Levy, Michele Ardolino, Barbara C. Vanderhyden
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-51217-1

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