Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection

Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection

Abstract Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range. Imbalances in metabolism and mitochondrial mechanisms can be sufficient to induce a depletion of ATP, thus altering retinal g...

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Bibliographic Details
Main Authors: Alessio Canovai, James R. Tribble, Melissa Jöe, Daniela Y. Westerlund, Rosario Amato, Ian A. Trounce, Massimo Dal Monte, Pete A. Williams
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Acta Neuropathologica Communications
Subjects:
Pyrroloquinoline quinone (PQQ)
Mitochondria
Metabolism
Metabolomics
ATP
Retinal ganglion cell
Online Access:https://doi.org/10.1186/s40478-023-01642-6

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