bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus
Aims. To evaluate plasma levels of transforming growth factor beta (TGFbeta1), basic fibroblast growth factor (bFGF), markers for nonspecific inflammatory process (interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), C-reactive protein (CRP)) and their putative correlation with advanced g...
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| Format: | Article |
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Endocrinology Research Centre
2013-09-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/819 |
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| author | Ekaterina Vladimirovna Ivannikova Konstantin Vladimirovich Melkozerov Victor Yur'evich Kalashnikov Sergey Anatol'evich Terekhin Irina Vladimirovna Kononenko Olga Mikhailovna Smirnova |
| author_facet | Ekaterina Vladimirovna Ivannikova Konstantin Vladimirovich Melkozerov Victor Yur'evich Kalashnikov Sergey Anatol'evich Terekhin Irina Vladimirovna Kononenko Olga Mikhailovna Smirnova |
| author_sort | Ekaterina Vladimirovna Ivannikova |
| collection | DOAJ |
| description | Aims. To evaluate plasma levels of transforming growth factor beta (TGFbeta1), basic fibroblast growth factor (bFGF), markers for nonspecific inflammatory process (interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), C-reactive protein (CRP)) and their putative correlation with advanced glycation end-products relative to diabetes compensation in patients with ischemic heart disease (IHD). Materials and Methods. 87 patients with IHD were enrolled in this study. All subjects underwent standard clinical examination, including laboratory assessment of glycemic parameters, lipid panel and renal function, with echocardiography, supplemented with coronary angiography. Analyses for study parameters were performed on samples obtained from aorta and, separately, from cubital vein during coronary angiography. Results. Diabetes mellitus in patients with IHD is firmly associated with TGFbeta1, IL-6 and CRP elevation in both arterial and venous plasma. TGFbeta1 positively correlates with lipid profile parameters. Plasma concentration of inflammatory markers and advanced glycation end-products positively correlates with the extent of coronary lesions in relation to the presence of diabetes mellitus. Conclusion. Our data suggests the interplay between connective tissue growth factors and lipid metabolism in the atherosclerotic process. |
| first_indexed | 2024-03-08T15:21:33Z |
| format | Article |
| id | doaj.art-9b0fbad2a6514d469b658ef544be064c |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:02:29Z |
| publishDate | 2013-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-9b0fbad2a6514d469b658ef544be064c2024-03-20T11:47:58ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782013-09-01163647010.14341/2072-0351-819799bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitusEkaterina Vladimirovna Ivannikova0Konstantin Vladimirovich Melkozerov1Victor Yur'evich Kalashnikov2Sergey Anatol'evich Terekhin3Irina Vladimirovna Kononenko4Olga Mikhailovna Smirnova5Endocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowAims. To evaluate plasma levels of transforming growth factor beta (TGFbeta1), basic fibroblast growth factor (bFGF), markers for nonspecific inflammatory process (interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), C-reactive protein (CRP)) and their putative correlation with advanced glycation end-products relative to diabetes compensation in patients with ischemic heart disease (IHD). Materials and Methods. 87 patients with IHD were enrolled in this study. All subjects underwent standard clinical examination, including laboratory assessment of glycemic parameters, lipid panel and renal function, with echocardiography, supplemented with coronary angiography. Analyses for study parameters were performed on samples obtained from aorta and, separately, from cubital vein during coronary angiography. Results. Diabetes mellitus in patients with IHD is firmly associated with TGFbeta1, IL-6 and CRP elevation in both arterial and venous plasma. TGFbeta1 positively correlates with lipid profile parameters. Plasma concentration of inflammatory markers and advanced glycation end-products positively correlates with the extent of coronary lesions in relation to the presence of diabetes mellitus. Conclusion. Our data suggests the interplay between connective tissue growth factors and lipid metabolism in the atherosclerotic process.https://www.dia-endojournals.ru/jour/article/view/819fibroblast growth factorsdiabetes mellitusischemic heart diseases |
| spellingShingle | Ekaterina Vladimirovna Ivannikova Konstantin Vladimirovich Melkozerov Victor Yur'evich Kalashnikov Sergey Anatol'evich Terekhin Irina Vladimirovna Kononenko Olga Mikhailovna Smirnova bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus Сахарный диабет fibroblast growth factors diabetes mellitus ischemic heart diseases |
| title | bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus |
| title_full | bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus |
| title_fullStr | bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus |
| title_full_unstemmed | bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus |
| title_short | bFGF and TGFbeta1 growth factors, inflammatory markers (IL-6, TNF-alpha, CRP) and advanced glycation end-products (AGE, RAGE) in patients with ischemic heart disease and type 2 diabetes mellitus |
| title_sort | bfgf and tgfbeta1 growth factors inflammatory markers il 6 tnf alpha crp and advanced glycation end products age rage in patients with ischemic heart disease and type 2 diabetes mellitus |
| topic | fibroblast growth factors diabetes mellitus ischemic heart diseases |
| url | https://www.dia-endojournals.ru/jour/article/view/819 |
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