Aniquinazolines A–D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans
Four new quinazolinone alkaloids, namely, aniquinazolines A–D (1–4), were isolated and identified from the culture of Aspergillus nidulans MA-143, an endophytic fungus obtained from the leaves of marine mangrove plant Rhizophora stylosa. The structures of the new compounds were elucidated by spectro...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-07-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/11/7/2682 |
| _version_ | 1811307127549984768 |
|---|---|
| author | Bin-Gui Wang Ming-Hui Wang Chun-Shun Li Chun-Yan An Xiao-Ming Li Gang-Ming Xu |
| author_facet | Bin-Gui Wang Ming-Hui Wang Chun-Shun Li Chun-Yan An Xiao-Ming Li Gang-Ming Xu |
| author_sort | Bin-Gui Wang |
| collection | DOAJ |
| description | Four new quinazolinone alkaloids, namely, aniquinazolines A–D (1–4), were isolated and identified from the culture of Aspergillus nidulans MA-143, an endophytic fungus obtained from the leaves of marine mangrove plant Rhizophora stylosa. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined on the basis of chiral HPLC analysis of the acidic hydrolysates. The structure for 1 was confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for antibacterial and cytotoxic activity as well as brine shrimp (Artemia salina) lethality. |
| first_indexed | 2024-04-13T08:59:06Z |
| format | Article |
| id | doaj.art-9b10d03499594faf95743decc9cbd3c0 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-13T08:59:06Z |
| publishDate | 2013-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-9b10d03499594faf95743decc9cbd3c02022-12-22T02:53:11ZengMDPI AGMarine Drugs1660-33972013-07-011172682269410.3390/md11072682Aniquinazolines A–D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulansBin-Gui WangMing-Hui WangChun-Shun LiChun-Yan AnXiao-Ming LiGang-Ming XuFour new quinazolinone alkaloids, namely, aniquinazolines A–D (1–4), were isolated and identified from the culture of Aspergillus nidulans MA-143, an endophytic fungus obtained from the leaves of marine mangrove plant Rhizophora stylosa. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined on the basis of chiral HPLC analysis of the acidic hydrolysates. The structure for 1 was confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for antibacterial and cytotoxic activity as well as brine shrimp (Artemia salina) lethality.http://www.mdpi.com/1660-3397/11/7/2682mangroveendophytic fungusAspergillus nidulanssecondary metabolitesbioactivity |
| spellingShingle | Bin-Gui Wang Ming-Hui Wang Chun-Shun Li Chun-Yan An Xiao-Ming Li Gang-Ming Xu Aniquinazolines A–D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans Marine Drugs mangrove endophytic fungus Aspergillus nidulans secondary metabolites bioactivity |
| title | Aniquinazolines A–D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans |
| title_full | Aniquinazolines A–D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans |
| title_fullStr | Aniquinazolines A–D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans |
| title_full_unstemmed | Aniquinazolines A–D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans |
| title_short | Aniquinazolines A–D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans |
| title_sort | aniquinazolines a d four new quinazolinone alkaloids from marine derived endophytic fungus aspergillus nidulans |
| topic | mangrove endophytic fungus Aspergillus nidulans secondary metabolites bioactivity |
| url | http://www.mdpi.com/1660-3397/11/7/2682 |
| work_keys_str_mv | AT binguiwang aniquinazolinesadfournewquinazolinonealkaloidsfrommarinederivedendophyticfungusaspergillusnidulans AT minghuiwang aniquinazolinesadfournewquinazolinonealkaloidsfrommarinederivedendophyticfungusaspergillusnidulans AT chunshunli aniquinazolinesadfournewquinazolinonealkaloidsfrommarinederivedendophyticfungusaspergillusnidulans AT chunyanan aniquinazolinesadfournewquinazolinonealkaloidsfrommarinederivedendophyticfungusaspergillusnidulans AT xiaomingli aniquinazolinesadfournewquinazolinonealkaloidsfrommarinederivedendophyticfungusaspergillusnidulans AT gangmingxu aniquinazolinesadfournewquinazolinonealkaloidsfrommarinederivedendophyticfungusaspergillusnidulans |