Enhanced Hemocompatibility of Silver Nanoparticles Using the Photocatalytic Properties of Titanium Dioxide
Silver nanoparticles (AgNPs) are widely used because of their excellent antimicrobial properties. However, the poor hemocompatibility limits the application of AgNPs in blood contact materials. General approaches to improve the hemocompatibility of AgNPs-containing surfaces are to construct barrier...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.855471/full |
| _version_ | 1819274171868250112 |
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| author | Xiao Chen Sheng Dai Luying Liu Peng Liu Peng Ye Yuzhen Liao Ansha Zhao Ping Yang Nan Huang Jiang Chen |
| author_facet | Xiao Chen Sheng Dai Luying Liu Peng Liu Peng Ye Yuzhen Liao Ansha Zhao Ping Yang Nan Huang Jiang Chen |
| author_sort | Xiao Chen |
| collection | DOAJ |
| description | Silver nanoparticles (AgNPs) are widely used because of their excellent antimicrobial properties. However, the poor hemocompatibility limits the application of AgNPs in blood contact materials. General approaches to improve the hemocompatibility of AgNPs-containing surfaces are to construct barrier layers or co-immobilize anticoagulant biomolecules. But such modification strategies are often cumbersome to prepare and have limited applications. Therefore, this study proposes a simple UV-photo-functionalization strategy to improve the hemocompatibility of AgNPs. We loaded AgNPs onto titanium dioxide (TiO2) nanoparticles to form a composite nanoparticles (Ag@TiO2NPs). Then, UV treatment was performed to the Ag@TiO2NPs, utilizing the diffusible photo-induced anticoagulant properties of TiO2 nanoparticles to enhance the hemocompatibility of AgNPs. After being deposited onto the PU surface, the photo-functionalized Ag@TiO2NPs coating showed excellent antibacterial properties against both Gram-positive/Gram-negative bacteria. Besides, In vitro and ex-vivo experiments demonstrated that the photo-functionalized Ag@TiO2NPs coating had desirable hemocompatibility. This modification strategy can provide a new solution idea to improve the hemocompatibility of metal nanoparticles. |
| first_indexed | 2024-12-23T23:04:12Z |
| format | Article |
| id | doaj.art-9b10ebf619754225b1c6b93f8be212b3 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-23T23:04:12Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-9b10ebf619754225b1c6b93f8be212b32022-12-21T17:26:51ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-02-011010.3389/fbioe.2022.855471855471Enhanced Hemocompatibility of Silver Nanoparticles Using the Photocatalytic Properties of Titanium DioxideXiao ChenSheng DaiLuying LiuPeng LiuPeng YeYuzhen LiaoAnsha ZhaoPing YangNan HuangJiang ChenSilver nanoparticles (AgNPs) are widely used because of their excellent antimicrobial properties. However, the poor hemocompatibility limits the application of AgNPs in blood contact materials. General approaches to improve the hemocompatibility of AgNPs-containing surfaces are to construct barrier layers or co-immobilize anticoagulant biomolecules. But such modification strategies are often cumbersome to prepare and have limited applications. Therefore, this study proposes a simple UV-photo-functionalization strategy to improve the hemocompatibility of AgNPs. We loaded AgNPs onto titanium dioxide (TiO2) nanoparticles to form a composite nanoparticles (Ag@TiO2NPs). Then, UV treatment was performed to the Ag@TiO2NPs, utilizing the diffusible photo-induced anticoagulant properties of TiO2 nanoparticles to enhance the hemocompatibility of AgNPs. After being deposited onto the PU surface, the photo-functionalized Ag@TiO2NPs coating showed excellent antibacterial properties against both Gram-positive/Gram-negative bacteria. Besides, In vitro and ex-vivo experiments demonstrated that the photo-functionalized Ag@TiO2NPs coating had desirable hemocompatibility. This modification strategy can provide a new solution idea to improve the hemocompatibility of metal nanoparticles.https://www.frontiersin.org/articles/10.3389/fbioe.2022.855471/fullSilver nanoparticles (AgNPs)Titanium dioxide (TiO2)hemocompatibilityantibacterial abilityUV treatment |
| spellingShingle | Xiao Chen Sheng Dai Luying Liu Peng Liu Peng Ye Yuzhen Liao Ansha Zhao Ping Yang Nan Huang Jiang Chen Enhanced Hemocompatibility of Silver Nanoparticles Using the Photocatalytic Properties of Titanium Dioxide Frontiers in Bioengineering and Biotechnology Silver nanoparticles (AgNPs) Titanium dioxide (TiO2) hemocompatibility antibacterial ability UV treatment |
| title | Enhanced Hemocompatibility of Silver Nanoparticles Using the Photocatalytic Properties of Titanium Dioxide |
| title_full | Enhanced Hemocompatibility of Silver Nanoparticles Using the Photocatalytic Properties of Titanium Dioxide |
| title_fullStr | Enhanced Hemocompatibility of Silver Nanoparticles Using the Photocatalytic Properties of Titanium Dioxide |
| title_full_unstemmed | Enhanced Hemocompatibility of Silver Nanoparticles Using the Photocatalytic Properties of Titanium Dioxide |
| title_short | Enhanced Hemocompatibility of Silver Nanoparticles Using the Photocatalytic Properties of Titanium Dioxide |
| title_sort | enhanced hemocompatibility of silver nanoparticles using the photocatalytic properties of titanium dioxide |
| topic | Silver nanoparticles (AgNPs) Titanium dioxide (TiO2) hemocompatibility antibacterial ability UV treatment |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.855471/full |
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