An exploratory human study investigating the influence of type 2 diabetes on macrophage phenotype after myocardial infarction
Background: Myocardial infarction (MI) is the primary cause of death in subjects with type 2 diabetes (T2D) and their in-hospital mortality after MI is still elevated compared with those without T2D. Therefore, it is of crucial importance to identify possible mechanisms of worse clinical outcomes an...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906723001409 |
| _version_ | 1797398577925849088 |
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| author | Claudine Moratal Joseph Murdaca Coralie Cruzel Amina Zamiti-Smondel Nathan Heme Florian Asarisi Jaap G. Neels Emile Ferrari Giulia Chinetti |
| author_facet | Claudine Moratal Joseph Murdaca Coralie Cruzel Amina Zamiti-Smondel Nathan Heme Florian Asarisi Jaap G. Neels Emile Ferrari Giulia Chinetti |
| author_sort | Claudine Moratal |
| collection | DOAJ |
| description | Background: Myocardial infarction (MI) is the primary cause of death in subjects with type 2 diabetes (T2D) and their in-hospital mortality after MI is still elevated compared with those without T2D. Therefore, it is of crucial importance to identify possible mechanisms of worse clinical outcomes and mortality in T2D subjects. Monocyte/macrophage-mediated immune response plays an important role in heart remodelling to limit functional deterioration after MI. Indeed, first pro-inflammatory macrophages digest damaged tissue, then anti-inflammatory macrophages become prevalent and promote tissue repair. Here, we hypothesize that the worse clinical outcomes in patients with T2D could be the consequence of a defective or a delayed polarization of macrophages toward an anti-inflammatory phenotype. Methods and results: In an exploratory human study, circulating monocytes from male patients with or without T2D at different time-points after MI were in vitro differentiated toward pro- or anti-inflammatory macrophages. The results of this pilot study suggest that the phenotype of circulating monocytes, as well as the pro- and anti-inflammatory macrophage polarization, or the kinetics of the pro- and anti-inflammatory polarization, is not influenced by T2D. Conclusion: Further studies will be necessary to understand the real contribution of macrophages after MI in humans. |
| first_indexed | 2024-03-09T01:27:30Z |
| format | Article |
| id | doaj.art-9b11076bd0494e89aa5d567757a41fca |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-03-09T01:27:30Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-9b11076bd0494e89aa5d567757a41fca2023-12-10T06:16:33ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672023-12-0149101309An exploratory human study investigating the influence of type 2 diabetes on macrophage phenotype after myocardial infarctionClaudine Moratal0Joseph Murdaca1Coralie Cruzel2Amina Zamiti-Smondel3Nathan Heme4Florian Asarisi5Jaap G. Neels6Emile Ferrari7Giulia Chinetti8Université Côte d’Azur, INSERM, C3M, Nice, FranceUniversité Côte d’Azur, INSERM, C3M, Nice, FranceCHU, Nice, FranceCHU, Nice, FranceCHU, Nice, FranceCHU, Nice, FranceUniversité Côte d’Azur, INSERM, C3M, Nice, France; Corresponding author at: INSERM 1065, Mediterranean Center for Molecular Medicine (C3M), Team 9: Metabolic Challenges of Immune Cells in Obesity, Diabetes and Cardiovascular Diseases, Bâtiment Universitaire Archimed, 151 Route de Ginestière, BP 2 3194, 06204 Nice Cedex 3, France.Université Côte d’Azur, CHU, INSERM, C3M, Nice, FranceUniversité Côte d’Azur, CHU, INSERM, C3M, Nice, FranceBackground: Myocardial infarction (MI) is the primary cause of death in subjects with type 2 diabetes (T2D) and their in-hospital mortality after MI is still elevated compared with those without T2D. Therefore, it is of crucial importance to identify possible mechanisms of worse clinical outcomes and mortality in T2D subjects. Monocyte/macrophage-mediated immune response plays an important role in heart remodelling to limit functional deterioration after MI. Indeed, first pro-inflammatory macrophages digest damaged tissue, then anti-inflammatory macrophages become prevalent and promote tissue repair. Here, we hypothesize that the worse clinical outcomes in patients with T2D could be the consequence of a defective or a delayed polarization of macrophages toward an anti-inflammatory phenotype. Methods and results: In an exploratory human study, circulating monocytes from male patients with or without T2D at different time-points after MI were in vitro differentiated toward pro- or anti-inflammatory macrophages. The results of this pilot study suggest that the phenotype of circulating monocytes, as well as the pro- and anti-inflammatory macrophage polarization, or the kinetics of the pro- and anti-inflammatory polarization, is not influenced by T2D. Conclusion: Further studies will be necessary to understand the real contribution of macrophages after MI in humans.http://www.sciencedirect.com/science/article/pii/S2352906723001409InflammationMonocytesType 2 diabetesCytokinesPolarizationMyocardial infarction |
| spellingShingle | Claudine Moratal Joseph Murdaca Coralie Cruzel Amina Zamiti-Smondel Nathan Heme Florian Asarisi Jaap G. Neels Emile Ferrari Giulia Chinetti An exploratory human study investigating the influence of type 2 diabetes on macrophage phenotype after myocardial infarction International Journal of Cardiology: Heart & Vasculature Inflammation Monocytes Type 2 diabetes Cytokines Polarization Myocardial infarction |
| title | An exploratory human study investigating the influence of type 2 diabetes on macrophage phenotype after myocardial infarction |
| title_full | An exploratory human study investigating the influence of type 2 diabetes on macrophage phenotype after myocardial infarction |
| title_fullStr | An exploratory human study investigating the influence of type 2 diabetes on macrophage phenotype after myocardial infarction |
| title_full_unstemmed | An exploratory human study investigating the influence of type 2 diabetes on macrophage phenotype after myocardial infarction |
| title_short | An exploratory human study investigating the influence of type 2 diabetes on macrophage phenotype after myocardial infarction |
| title_sort | exploratory human study investigating the influence of type 2 diabetes on macrophage phenotype after myocardial infarction |
| topic | Inflammation Monocytes Type 2 diabetes Cytokines Polarization Myocardial infarction |
| url | http://www.sciencedirect.com/science/article/pii/S2352906723001409 |
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