Fatigue and quality-of-life in the year following SARS-Cov2 infection
Abstract Background The SARS-COV2 pandemic has been ongoing worldwide since at least 2 years. In severe cases, this infection triggers acute respiratory distress syndrome and quasi-systemic damage with a wide range of symptoms. Long-term physical and psychological consequences of this infection are...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-022-07517-w |
| _version_ | 1818236935673479168 |
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| author | Peter-Joe Noujaim Damien Jolly Claire Coutureau Lukshe Kanagaratnam |
| author_facet | Peter-Joe Noujaim Damien Jolly Claire Coutureau Lukshe Kanagaratnam |
| author_sort | Peter-Joe Noujaim |
| collection | DOAJ |
| description | Abstract Background The SARS-COV2 pandemic has been ongoing worldwide since at least 2 years. In severe cases, this infection triggers acute respiratory distress syndrome and quasi-systemic damage with a wide range of symptoms. Long-term physical and psychological consequences of this infection are therefore naturally present among these patients. The aim of this study was to describe the state of health of these patients at 6 (M6) and 12 months (M12) after infection onset, and compare quality-of-life (QOL) and fatigue at these time-points. Methods A prospective cohort study was set up at Reims University Hospital. Patients were clinically assessed at M6 and M12. Three scores were calculated to describe patient’s status: the modified Medical Research Council score (mMRC) used to determine dyspnoea state, the Fatigue Severity Scale (FSS) and the Short Form 12 (SF12) that was carried out to determine the QOL both mentally and physically (MCS12 and PCS12). Descriptive analysis and comparison of scores between M6 and M12 were made. Results 120 patients completed both follow-up consultations. Overall, about 40% of the patients presented dyspnoea symptoms. The median mMRC score was 1 Interquartile ranges (IQR) = [0–2] at the two assessment. Concerning FSS scores, 35% and 44% of patients experienced fatigue at both follow-ups. The two scores of SF12 were lower than the general population standard scores. The mean PCS12 score was 42.85 (95% confidence interval (95% CI [41.05–44.65])) and mean MCS12 score of 46.70 (95% CI [45.34–48.06]) at 6 months. At 12 months, the mean PCS12 score was 42.18 (95% confidence interval (95% CI [40.46–43.89])) and mean MCS12 score of 47.13 (95% CI [45.98–48.28]). No difference was found between SF12 scores at 6 and 12 months. Conclusions This study pinpoints the persistence of fatigue and a low mental and physical QOL compared to population norms even after 1 year following infection. It also supports the claims of mental or psychological alterations due to infection by this new virus, hence a lower overall QOL in patients. |
| first_indexed | 2024-12-12T12:17:46Z |
| format | Article |
| id | doaj.art-9b11eb2564ed472dbaf824fe588f8d42 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-12T12:17:46Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-9b11eb2564ed472dbaf824fe588f8d422022-12-22T00:24:43ZengBMCBMC Infectious Diseases1471-23342022-06-012211810.1186/s12879-022-07517-wFatigue and quality-of-life in the year following SARS-Cov2 infectionPeter-Joe Noujaim0Damien Jolly1Claire Coutureau2Lukshe Kanagaratnam3CHU Reims, Unité d’Aide MéthodologiqueCHU Reims, Unité d’Aide MéthodologiqueCHU Reims, Unité d’Aide MéthodologiqueCHU Reims, Unité d’Aide MéthodologiqueAbstract Background The SARS-COV2 pandemic has been ongoing worldwide since at least 2 years. In severe cases, this infection triggers acute respiratory distress syndrome and quasi-systemic damage with a wide range of symptoms. Long-term physical and psychological consequences of this infection are therefore naturally present among these patients. The aim of this study was to describe the state of health of these patients at 6 (M6) and 12 months (M12) after infection onset, and compare quality-of-life (QOL) and fatigue at these time-points. Methods A prospective cohort study was set up at Reims University Hospital. Patients were clinically assessed at M6 and M12. Three scores were calculated to describe patient’s status: the modified Medical Research Council score (mMRC) used to determine dyspnoea state, the Fatigue Severity Scale (FSS) and the Short Form 12 (SF12) that was carried out to determine the QOL both mentally and physically (MCS12 and PCS12). Descriptive analysis and comparison of scores between M6 and M12 were made. Results 120 patients completed both follow-up consultations. Overall, about 40% of the patients presented dyspnoea symptoms. The median mMRC score was 1 Interquartile ranges (IQR) = [0–2] at the two assessment. Concerning FSS scores, 35% and 44% of patients experienced fatigue at both follow-ups. The two scores of SF12 were lower than the general population standard scores. The mean PCS12 score was 42.85 (95% confidence interval (95% CI [41.05–44.65])) and mean MCS12 score of 46.70 (95% CI [45.34–48.06]) at 6 months. At 12 months, the mean PCS12 score was 42.18 (95% confidence interval (95% CI [40.46–43.89])) and mean MCS12 score of 47.13 (95% CI [45.98–48.28]). No difference was found between SF12 scores at 6 and 12 months. Conclusions This study pinpoints the persistence of fatigue and a low mental and physical QOL compared to population norms even after 1 year following infection. It also supports the claims of mental or psychological alterations due to infection by this new virus, hence a lower overall QOL in patients.https://doi.org/10.1186/s12879-022-07517-wCOVID-19FatigueQOLSF12Dyspneoa |
| spellingShingle | Peter-Joe Noujaim Damien Jolly Claire Coutureau Lukshe Kanagaratnam Fatigue and quality-of-life in the year following SARS-Cov2 infection BMC Infectious Diseases COVID-19 Fatigue QOL SF12 Dyspneoa |
| title | Fatigue and quality-of-life in the year following SARS-Cov2 infection |
| title_full | Fatigue and quality-of-life in the year following SARS-Cov2 infection |
| title_fullStr | Fatigue and quality-of-life in the year following SARS-Cov2 infection |
| title_full_unstemmed | Fatigue and quality-of-life in the year following SARS-Cov2 infection |
| title_short | Fatigue and quality-of-life in the year following SARS-Cov2 infection |
| title_sort | fatigue and quality of life in the year following sars cov2 infection |
| topic | COVID-19 Fatigue QOL SF12 Dyspneoa |
| url | https://doi.org/10.1186/s12879-022-07517-w |
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