Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms

Respiratory viruses from diverse families cocirculate in human populations and are frequently detected within the same host. Although clinical studies suggest that infection by multiple different respiratory viruses may alter disease severity, animal models in which we can control the doses, timing,...

Full description

Bibliographic Details
Main Authors: James T. Van Leuven, Andres J. Gonzalez, Emmanuel C. Ijezie, Alexander Q. Wixom, John L. Clary, Maricris N. Naranjo, Benjamin J. Ridenhour, Craig R. Miller, Tanya A. Miura
Format: Article
Language:English
Published: American Society for Microbiology 2021-06-01
Series:mSphere
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00479-21
_version_ 1819224811690262528
author James T. Van Leuven
Andres J. Gonzalez
Emmanuel C. Ijezie
Alexander Q. Wixom
John L. Clary
Maricris N. Naranjo
Benjamin J. Ridenhour
Craig R. Miller
Tanya A. Miura
author_facet James T. Van Leuven
Andres J. Gonzalez
Emmanuel C. Ijezie
Alexander Q. Wixom
John L. Clary
Maricris N. Naranjo
Benjamin J. Ridenhour
Craig R. Miller
Tanya A. Miura
author_sort James T. Van Leuven
collection DOAJ
description Respiratory viruses from diverse families cocirculate in human populations and are frequently detected within the same host. Although clinical studies suggest that infection by multiple different respiratory viruses may alter disease severity, animal models in which we can control the doses, timing, and strains of coinfecting viruses are critical to understanding how coinfection affects disease severity.
first_indexed 2024-12-23T09:59:38Z
format Article
id doaj.art-9b12696f76094b6c8c8fdb1b37cf1208
institution Directory Open Access Journal
issn 2379-5042
language English
last_indexed 2024-12-23T09:59:38Z
publishDate 2021-06-01
publisher American Society for Microbiology
record_format Article
series mSphere
spelling doaj.art-9b12696f76094b6c8c8fdb1b37cf12082022-12-21T17:51:17ZengAmerican Society for MicrobiologymSphere2379-50422021-06-016310.1128/mSphere.00479-21Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent MechanismsJames T. Van Leuven0Andres J. Gonzalez1Emmanuel C. Ijezie2Alexander Q. Wixom3John L. Clary4Maricris N. Naranjo5Benjamin J. Ridenhour6Craig R. Miller7Tanya A. Miura8Institute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho, USAInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho, USAInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho, USADepartment of Plant Sciences, University of Idaho, Moscow, Idaho, USAInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho, USADepartment of Biological Sciences, University of Idaho, Moscow, Idaho, USAInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho, USAInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho, USAInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, Idaho, USARespiratory viruses from diverse families cocirculate in human populations and are frequently detected within the same host. Although clinical studies suggest that infection by multiple different respiratory viruses may alter disease severity, animal models in which we can control the doses, timing, and strains of coinfecting viruses are critical to understanding how coinfection affects disease severity.https://journals.asm.org/doi/10.1128/mSphere.00479-21
spellingShingle James T. Van Leuven
Andres J. Gonzalez
Emmanuel C. Ijezie
Alexander Q. Wixom
John L. Clary
Maricris N. Naranjo
Benjamin J. Ridenhour
Craig R. Miller
Tanya A. Miura
Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms
mSphere
title Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms
title_full Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms
title_fullStr Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms
title_full_unstemmed Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms
title_short Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms
title_sort rhinovirus reduces the severity of subsequent respiratory viral infections by interferon dependent and independent mechanisms
url https://journals.asm.org/doi/10.1128/mSphere.00479-21
work_keys_str_mv AT jamestvanleuven rhinovirusreducestheseverityofsubsequentrespiratoryviralinfectionsbyinterferondependentandindependentmechanisms
AT andresjgonzalez rhinovirusreducestheseverityofsubsequentrespiratoryviralinfectionsbyinterferondependentandindependentmechanisms
AT emmanuelcijezie rhinovirusreducestheseverityofsubsequentrespiratoryviralinfectionsbyinterferondependentandindependentmechanisms
AT alexanderqwixom rhinovirusreducestheseverityofsubsequentrespiratoryviralinfectionsbyinterferondependentandindependentmechanisms
AT johnlclary rhinovirusreducestheseverityofsubsequentrespiratoryviralinfectionsbyinterferondependentandindependentmechanisms
AT maricrisnnaranjo rhinovirusreducestheseverityofsubsequentrespiratoryviralinfectionsbyinterferondependentandindependentmechanisms
AT benjaminjridenhour rhinovirusreducestheseverityofsubsequentrespiratoryviralinfectionsbyinterferondependentandindependentmechanisms
AT craigrmiller rhinovirusreducestheseverityofsubsequentrespiratoryviralinfectionsbyinterferondependentandindependentmechanisms
AT tanyaamiura rhinovirusreducestheseverityofsubsequentrespiratoryviralinfectionsbyinterferondependentandindependentmechanisms