Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells
<p>Abstract</p> <p>Background</p> <p>Posttraumatic stress disorder (PTSD) is associated with an enhanced risk for cardiovascular and other inflammatory diseases. Chronic low-level inflammation has been suggested as a potential mechanism linking these conditions.</p&g...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2013-01-01
|
| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-244X/13/40 |
| _version_ | 1819182674251612160 |
|---|---|
| author | Gola Hannah Engler Harald Sommershof Annette Adenauer Hannah Kolassa Stephan Schedlowski Manfred Groettrup Marcus Elbert Thomas Kolassa Iris-Tatjana |
| author_facet | Gola Hannah Engler Harald Sommershof Annette Adenauer Hannah Kolassa Stephan Schedlowski Manfred Groettrup Marcus Elbert Thomas Kolassa Iris-Tatjana |
| author_sort | Gola Hannah |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Posttraumatic stress disorder (PTSD) is associated with an enhanced risk for cardiovascular and other inflammatory diseases. Chronic low-level inflammation has been suggested as a potential mechanism linking these conditions.</p> <p>Methods</p> <p>We investigated plasma cytokine levels as well as spontaneous and lipopolysaccharide (LPS)-stimulated cytokine production by peripheral blood mononuclear cells (PBMCs) in a group of 35 severely traumatized PTSD patients compared to 25 healthy controls.</p> <p>Results</p> <p>Spontaneous production of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α by isolated PBMCs was significantly higher in the PTSD compared to the control group and even correlated with PTSD symptom severity within the PTSD group. In contrast, circulating plasma levels of pro- and anti-inflammatory cytokines such as IL-6, IL-8, IL-10, TNF-α, or monocyte chemotactic protein (MCP)-1 were not significantly altered in PTSD patients compared to healthy controls.</p> <p>Conclusions</p> <p>Our findings indicate that PBMCs of PTSD patients are already pre-activated <it>in vivo</it>, providing further evidence for low-grade inflammation in PTSD. This might possibly represent one psychobiological pathway from PTSD to poor physical health.</p> |
| first_indexed | 2024-12-22T22:49:53Z |
| format | Article |
| id | doaj.art-9b12c86957604b849bf22e35239da7e4 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-22T22:49:53Z |
| publishDate | 2013-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-9b12c86957604b849bf22e35239da7e42022-12-21T18:09:59ZengBMCBMC Psychiatry1471-244X2013-01-011314010.1186/1471-244X-13-40Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cellsGola HannahEngler HaraldSommershof AnnetteAdenauer HannahKolassa StephanSchedlowski ManfredGroettrup MarcusElbert ThomasKolassa Iris-Tatjana<p>Abstract</p> <p>Background</p> <p>Posttraumatic stress disorder (PTSD) is associated with an enhanced risk for cardiovascular and other inflammatory diseases. Chronic low-level inflammation has been suggested as a potential mechanism linking these conditions.</p> <p>Methods</p> <p>We investigated plasma cytokine levels as well as spontaneous and lipopolysaccharide (LPS)-stimulated cytokine production by peripheral blood mononuclear cells (PBMCs) in a group of 35 severely traumatized PTSD patients compared to 25 healthy controls.</p> <p>Results</p> <p>Spontaneous production of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α by isolated PBMCs was significantly higher in the PTSD compared to the control group and even correlated with PTSD symptom severity within the PTSD group. In contrast, circulating plasma levels of pro- and anti-inflammatory cytokines such as IL-6, IL-8, IL-10, TNF-α, or monocyte chemotactic protein (MCP)-1 were not significantly altered in PTSD patients compared to healthy controls.</p> <p>Conclusions</p> <p>Our findings indicate that PBMCs of PTSD patients are already pre-activated <it>in vivo</it>, providing further evidence for low-grade inflammation in PTSD. This might possibly represent one psychobiological pathway from PTSD to poor physical health.</p>http://www.biomedcentral.com/1471-244X/13/40Posttraumatic stress disorderImmune systemCytokinesPro-inflammatory cytokinesTraumatic stressInflammation |
| spellingShingle | Gola Hannah Engler Harald Sommershof Annette Adenauer Hannah Kolassa Stephan Schedlowski Manfred Groettrup Marcus Elbert Thomas Kolassa Iris-Tatjana Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells BMC Psychiatry Posttraumatic stress disorder Immune system Cytokines Pro-inflammatory cytokines Traumatic stress Inflammation |
| title | Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells |
| title_full | Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells |
| title_fullStr | Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells |
| title_full_unstemmed | Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells |
| title_short | Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells |
| title_sort | posttraumatic stress disorder is associated with an enhanced spontaneous production of pro inflammatory cytokines by peripheral blood mononuclear cells |
| topic | Posttraumatic stress disorder Immune system Cytokines Pro-inflammatory cytokines Traumatic stress Inflammation |
| url | http://www.biomedcentral.com/1471-244X/13/40 |
| work_keys_str_mv | AT golahannah posttraumaticstressdisorderisassociatedwithanenhancedspontaneousproductionofproinflammatorycytokinesbyperipheralbloodmononuclearcells AT englerharald posttraumaticstressdisorderisassociatedwithanenhancedspontaneousproductionofproinflammatorycytokinesbyperipheralbloodmononuclearcells AT sommershofannette posttraumaticstressdisorderisassociatedwithanenhancedspontaneousproductionofproinflammatorycytokinesbyperipheralbloodmononuclearcells AT adenauerhannah posttraumaticstressdisorderisassociatedwithanenhancedspontaneousproductionofproinflammatorycytokinesbyperipheralbloodmononuclearcells AT kolassastephan posttraumaticstressdisorderisassociatedwithanenhancedspontaneousproductionofproinflammatorycytokinesbyperipheralbloodmononuclearcells AT schedlowskimanfred posttraumaticstressdisorderisassociatedwithanenhancedspontaneousproductionofproinflammatorycytokinesbyperipheralbloodmononuclearcells AT groettrupmarcus posttraumaticstressdisorderisassociatedwithanenhancedspontaneousproductionofproinflammatorycytokinesbyperipheralbloodmononuclearcells AT elbertthomas posttraumaticstressdisorderisassociatedwithanenhancedspontaneousproductionofproinflammatorycytokinesbyperipheralbloodmononuclearcells AT kolassairistatjana posttraumaticstressdisorderisassociatedwithanenhancedspontaneousproductionofproinflammatorycytokinesbyperipheralbloodmononuclearcells |