THE ROLE OF CATECHOLAMINES IN THE DEVELOPMENT OF IMMUNOSUPPRESSION IN SEVERE TRAUMATIC BRAIN INJURY
Objective. In the study included 45 patients with isolated severe traumatic brain injury in the acute period of this disease. Two groups were identified: the first group – 20 surviving patients, the second group – 25 deceased patients. The study to shown the role of catecholamines in the development...
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| Format: | Article |
| Language: | Russian |
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The Publishing House Medicine and Enlightenment
2019-02-01
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| Series: | Medicina v Kuzbasse |
| Subjects: | |
| Online Access: | http://mednauki.ru/index.php/MK/article/view/322 |
| _version_ | 1818534744256675840 |
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| author | Тамара Ивановна Борщикова Наталья Николаевна Епифанцева Сергей Людовикович Кан Сергей Николаевич Филимонов |
| author_facet | Тамара Ивановна Борщикова Наталья Николаевна Епифанцева Сергей Людовикович Кан Сергей Николаевич Филимонов |
| author_sort | Тамара Ивановна Борщикова |
| collection | DOAJ |
| description | Objective. In the study included 45 patients with isolated severe traumatic brain injury in the acute period of this disease. Two groups were identified: the first group – 20 surviving patients, the second group – 25 deceased patients. The study to shown the role of catecholamines in the development of immunosuppression in the acute period of the severe traumatic brain injury.
Methods. On the 1st, 3rd, 5th day after severe traumatic brain injury we determined the subpopulations of lymphocytes by the presence of surface cellular antigens. We used the method of indirect immunofluorescence with monoclonal antibodies on cytofluorimeter «Citomix FC500» for determining CD3+, CD4+, CD8+, CD16+, CD20+-lymphocytes. We determined the levels of epinephrine and norepinephrine in urine by the kit «CatCombi» (ELISA) on the 1st and 3rd day of the post-traumatic period.
Conclusions. The raise of the levels epinephrine and norepinephrine in severe traumatic brain injury adduce to the failure of the cellular immunity with decrease the subpopulations of lymphocytes: CD3+, CD4+, CD8+, CD16+ lymphocytes. |
| first_indexed | 2024-12-11T18:15:33Z |
| format | Article |
| id | doaj.art-9b12cc18d5c3474db8e77e42fe5d4e31 |
| institution | Directory Open Access Journal |
| issn | 1819-0901 |
| language | Russian |
| last_indexed | 2024-12-11T18:15:33Z |
| publishDate | 2019-02-01 |
| publisher | The Publishing House Medicine and Enlightenment |
| record_format | Article |
| series | Medicina v Kuzbasse |
| spelling | doaj.art-9b12cc18d5c3474db8e77e42fe5d4e312022-12-22T00:55:27ZrusThe Publishing House Medicine and EnlightenmentMedicina v Kuzbasse1819-09012019-02-01181510284THE ROLE OF CATECHOLAMINES IN THE DEVELOPMENT OF IMMUNOSUPPRESSION IN SEVERE TRAUMATIC BRAIN INJURYТамара Ивановна Борщикова0Наталья Николаевна Епифанцева1Сергей Людовикович Кан2Сергей Николаевич Филимонов3НГИУВ – филиал ФГБОУ ДПО РМАНПО Минздрава России, г. НовокузнецкНГИУВ – филиал ФГБОУ ДПО РМАНПО Минздрава России, г. НовокузнецкНГИУВ – филиал ФГБОУ ДПО РМАНПО Минздрава России, г. НовокузнецкФГБНУ НИИ КПГПЗ, г. НовокузнецкObjective. In the study included 45 patients with isolated severe traumatic brain injury in the acute period of this disease. Two groups were identified: the first group – 20 surviving patients, the second group – 25 deceased patients. The study to shown the role of catecholamines in the development of immunosuppression in the acute period of the severe traumatic brain injury. Methods. On the 1st, 3rd, 5th day after severe traumatic brain injury we determined the subpopulations of lymphocytes by the presence of surface cellular antigens. We used the method of indirect immunofluorescence with monoclonal antibodies on cytofluorimeter «Citomix FC500» for determining CD3+, CD4+, CD8+, CD16+, CD20+-lymphocytes. We determined the levels of epinephrine and norepinephrine in urine by the kit «CatCombi» (ELISA) on the 1st and 3rd day of the post-traumatic period. Conclusions. The raise of the levels epinephrine and norepinephrine in severe traumatic brain injury adduce to the failure of the cellular immunity with decrease the subpopulations of lymphocytes: CD3+, CD4+, CD8+, CD16+ lymphocytes.http://mednauki.ru/index.php/MK/article/view/322тяжёлая черепно-мозговая травмаиммуносупрессиякатехоламины |
| spellingShingle | Тамара Ивановна Борщикова Наталья Николаевна Епифанцева Сергей Людовикович Кан Сергей Николаевич Филимонов THE ROLE OF CATECHOLAMINES IN THE DEVELOPMENT OF IMMUNOSUPPRESSION IN SEVERE TRAUMATIC BRAIN INJURY Medicina v Kuzbasse тяжёлая черепно-мозговая травма иммуносупрессия катехоламины |
| title | THE ROLE OF CATECHOLAMINES IN THE DEVELOPMENT OF IMMUNOSUPPRESSION IN SEVERE TRAUMATIC BRAIN INJURY |
| title_full | THE ROLE OF CATECHOLAMINES IN THE DEVELOPMENT OF IMMUNOSUPPRESSION IN SEVERE TRAUMATIC BRAIN INJURY |
| title_fullStr | THE ROLE OF CATECHOLAMINES IN THE DEVELOPMENT OF IMMUNOSUPPRESSION IN SEVERE TRAUMATIC BRAIN INJURY |
| title_full_unstemmed | THE ROLE OF CATECHOLAMINES IN THE DEVELOPMENT OF IMMUNOSUPPRESSION IN SEVERE TRAUMATIC BRAIN INJURY |
| title_short | THE ROLE OF CATECHOLAMINES IN THE DEVELOPMENT OF IMMUNOSUPPRESSION IN SEVERE TRAUMATIC BRAIN INJURY |
| title_sort | role of catecholamines in the development of immunosuppression in severe traumatic brain injury |
| topic | тяжёлая черепно-мозговая травма иммуносупрессия катехоламины |
| url | http://mednauki.ru/index.php/MK/article/view/322 |
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