Leptin/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages

Abstract Background Obesity-related asthma is a kind of nonallergic asthma with excessive neutrophil infiltration in the airways. However, the underlying mechanisms have been poorly elucidated. Among the adipokines related to obesity, leptin is related to the inflammatory response. However, little i...

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Bibliographic Details
Main Authors: Yang Wang, Rongjun Wan, Chengping Hu
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Molecular Medicine
Subjects:
Online Access:https://doi.org/10.1186/s10020-023-00702-w