Analysis of antibody response to measles vaccine with censored data
Payesh2010; 9: 77-82Accepted for publication: 23 February 2009[EPub a head of print-1 November 2009] Objective(s): Analysis of measles serum antibody responses is an important tool for evaluating the level of immunity in vaccinated people and for determining the factors which influence protective im...
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| Format: | Article |
| Language: | fas |
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Iranian Institute for Health Sciences Research
2010-01-01
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| Series: | Payesh |
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| Online Access: | http://payeshjournal.ir/article-1-591-en.html |
| _version_ | 1828804178407849984 |
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| author | Ali Reza Hatami Anooshirvan Kazemnejad Ebrahim Hajizadeh Farzaneh Sabahi Hamid Reza Varmazyar |
| author_facet | Ali Reza Hatami Anooshirvan Kazemnejad Ebrahim Hajizadeh Farzaneh Sabahi Hamid Reza Varmazyar |
| author_sort | Ali Reza Hatami |
| collection | DOAJ |
| description | Payesh2010; 9: 77-82Accepted for publication: 23 February 2009[EPub a head of print-1 November 2009]
Objective(s): Analysis of measles serum antibody responses is an important tool for evaluating the level of immunity in vaccinated people and for determining the factors which influence protective immunity. Usually antibody concentration values which are determined by quantitative assays are left censored, so standard analysis such as simple linear regression model may not be appropriate.Methods: Measles antibodies were measured using Enzyme Linked Immunosorbent Assay (ELISA) in 200 person aged 5-25 years before and after vaccination. A censored regression model proposed in order to reduce the effects of censored data in parameter estimating.Results: Twenty two persons (11 percent) of the sample had titer below detection limit which made censored data. 83 percent of children and teenagers (less than 16 years) and 88 percent of participant aged 16 and more were protective against measles disease, but there was no statistically significance between age and immunity (P= 0.4).Conclusion: Although the number of females who had protective antibodies against measles was less than males, they possessed an average titer 42 percent higher than males (without considering covariates). This proportion changed into 39% by using the censored regression model and adjusting with respect to “antibody titer before vaccination”. Both ratios showed higher vaccine- induced protection in females (P< 0.05). |
| first_indexed | 2024-12-12T07:36:32Z |
| format | Article |
| id | doaj.art-9b13c9d028d54bdc907f48534f3d6861 |
| institution | Directory Open Access Journal |
| issn | 1680-7626 2008-4536 |
| language | fas |
| last_indexed | 2024-12-12T07:36:32Z |
| publishDate | 2010-01-01 |
| publisher | Iranian Institute for Health Sciences Research |
| record_format | Article |
| series | Payesh |
| spelling | doaj.art-9b13c9d028d54bdc907f48534f3d68612022-12-22T00:32:54ZfasIranian Institute for Health Sciences ResearchPayesh1680-76262008-45362010-01-01917782Analysis of antibody response to measles vaccine with censored dataAli Reza Hatami0Anooshirvan Kazemnejad1Ebrahim Hajizadeh2Farzaneh Sabahi3Hamid Reza Varmazyar4 Payesh2010; 9: 77-82Accepted for publication: 23 February 2009[EPub a head of print-1 November 2009] Objective(s): Analysis of measles serum antibody responses is an important tool for evaluating the level of immunity in vaccinated people and for determining the factors which influence protective immunity. Usually antibody concentration values which are determined by quantitative assays are left censored, so standard analysis such as simple linear regression model may not be appropriate.Methods: Measles antibodies were measured using Enzyme Linked Immunosorbent Assay (ELISA) in 200 person aged 5-25 years before and after vaccination. A censored regression model proposed in order to reduce the effects of censored data in parameter estimating.Results: Twenty two persons (11 percent) of the sample had titer below detection limit which made censored data. 83 percent of children and teenagers (less than 16 years) and 88 percent of participant aged 16 and more were protective against measles disease, but there was no statistically significance between age and immunity (P= 0.4).Conclusion: Although the number of females who had protective antibodies against measles was less than males, they possessed an average titer 42 percent higher than males (without considering covariates). This proportion changed into 39% by using the censored regression model and adjusting with respect to “antibody titer before vaccination”. Both ratios showed higher vaccine- induced protection in females (P< 0.05).http://payeshjournal.ir/article-1-591-en.htmlantibodymeaslesvaccinationcensoringcensored regression model |
| spellingShingle | Ali Reza Hatami Anooshirvan Kazemnejad Ebrahim Hajizadeh Farzaneh Sabahi Hamid Reza Varmazyar Analysis of antibody response to measles vaccine with censored data Payesh antibody measles vaccination censoring censored regression model |
| title | Analysis of antibody response to measles vaccine with censored data |
| title_full | Analysis of antibody response to measles vaccine with censored data |
| title_fullStr | Analysis of antibody response to measles vaccine with censored data |
| title_full_unstemmed | Analysis of antibody response to measles vaccine with censored data |
| title_short | Analysis of antibody response to measles vaccine with censored data |
| title_sort | analysis of antibody response to measles vaccine with censored data |
| topic | antibody measles vaccination censoring censored regression model |
| url | http://payeshjournal.ir/article-1-591-en.html |
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