Juvenile murine models of prediabetes and type 2 diabetes develop neuropathy

Juvenile murine models of prediabetes and type 2 diabetes develop neuropathy

Peripheral neuropathy (neuropathy) is a common complication of obesity and type 2 diabetes in children and adolescents. To model this complication in mice, 5-week-old male C57BL/6J mice were fed a high-fat diet to induce diet-induced obesity (DIO), a model of prediabetes, and a cohort of these anima...

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Bibliographic Details
Main Authors: Phillipe D. O'Brien, Lucy M. Hinder, Amy E. Rumora, John M. Hayes, Jacqueline R. Dauch, Carey Backus, Faye E. Mendelson, Eva L. Feldman
Format: Article
Language:English
Published: The Company of Biologists 2018-12-01
Series:Disease Models & Mechanisms
Subjects:
Mouse models
Obesity
Peripheral neuropathy
Prediabetes
Type 2 diabetes
Online Access:http://dmm.biologists.org/content/11/12/dmm037374

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