Supplementation with Fermented Rice Bran Attenuates Muscle Atrophy in a Diabetic Rat Model
Fermented rice bran (FRB), a prospective supplement, has been proven to ameliorate certain medical conditions. However, its nutraceutical effect on muscle atrophy has never been investigated. The present study aimed to evaluate the effect of FRB on muscle atrophy in a streptozotocin (STZ)-induced di...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/8/2409 |
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| author | Tubagus Bahtiar Rusbana Afifah Zahra Agista Wahyu Dwi Saputra Yusuke Ohsaki Kouichi Watanabe Ardy Ardiansyah Slamet Budijanto Takuya Koseki Hisashi Aso Michio Komai Hitoshi Shirakawa |
| author_facet | Tubagus Bahtiar Rusbana Afifah Zahra Agista Wahyu Dwi Saputra Yusuke Ohsaki Kouichi Watanabe Ardy Ardiansyah Slamet Budijanto Takuya Koseki Hisashi Aso Michio Komai Hitoshi Shirakawa |
| author_sort | Tubagus Bahtiar Rusbana |
| collection | DOAJ |
| description | Fermented rice bran (FRB), a prospective supplement, has been proven to ameliorate certain medical conditions. However, its nutraceutical effect on muscle atrophy has never been investigated. The present study aimed to evaluate the effect of FRB on muscle atrophy in a streptozotocin (STZ)-induced diabetic rat model. Three groups of Sprague-Dawley rats, namely the control, STZ, and FRB groups, were treated as follows. The diabetic groups (STZ and FRB) were injected intraperitoneally with STZ (40 mg/kg BW), whereas the control group was injected with the vehicle. The STZ and control groups were fed the AIN93M diet, and the FRB group was fed 10% of FRB based on the AIN93M diet. The diabetic groups had reduced muscle size compared to the control group; however, these changes were alleviated in the FRB group. Moreover, the FRB group had a significantly lower expression of FBXO32/Atrogin-1 and TRIM63/MuRF1 (<i>p</i> < 0.05) due to blocked NF-κB activation. In conclusion, the anti-inflammatory effect of FRB may be beneficial for ameliorating muscle atrophy in diabetic conditions. |
| first_indexed | 2024-03-10T17:35:43Z |
| format | Article |
| id | doaj.art-9b1506a2b69640a5b961b707ecf1ffa7 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T17:35:43Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-9b1506a2b69640a5b961b707ecf1ffa72023-11-20T09:52:19ZengMDPI AGNutrients2072-66432020-08-01128240910.3390/nu12082409Supplementation with Fermented Rice Bran Attenuates Muscle Atrophy in a Diabetic Rat ModelTubagus Bahtiar Rusbana0Afifah Zahra Agista1Wahyu Dwi Saputra2Yusuke Ohsaki3Kouichi Watanabe4Ardy Ardiansyah5Slamet Budijanto6Takuya Koseki7Hisashi Aso8Michio Komai9Hitoshi Shirakawa10Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, JapanLaboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, JapanLaboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, JapanLaboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, JapanCellular Biology Laboratory, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, JapanDepartment of Food Technology, Universitas Bakrie, Jakarta 12920, IndonesiaFaculty of Agricultural Engineering and Technology, IPB University, Bogor 16680, IndonesiaFaculty of Agriculture, Yamagata University, Tsuruoka 997-8555, JapanCellular Biology Laboratory, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, JapanLaboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, JapanLaboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, JapanFermented rice bran (FRB), a prospective supplement, has been proven to ameliorate certain medical conditions. However, its nutraceutical effect on muscle atrophy has never been investigated. The present study aimed to evaluate the effect of FRB on muscle atrophy in a streptozotocin (STZ)-induced diabetic rat model. Three groups of Sprague-Dawley rats, namely the control, STZ, and FRB groups, were treated as follows. The diabetic groups (STZ and FRB) were injected intraperitoneally with STZ (40 mg/kg BW), whereas the control group was injected with the vehicle. The STZ and control groups were fed the AIN93M diet, and the FRB group was fed 10% of FRB based on the AIN93M diet. The diabetic groups had reduced muscle size compared to the control group; however, these changes were alleviated in the FRB group. Moreover, the FRB group had a significantly lower expression of FBXO32/Atrogin-1 and TRIM63/MuRF1 (<i>p</i> < 0.05) due to blocked NF-κB activation. In conclusion, the anti-inflammatory effect of FRB may be beneficial for ameliorating muscle atrophy in diabetic conditions.https://www.mdpi.com/2072-6643/12/8/2409fermented rice branmuscle atrophydiabetes mellitusstreptozotocinFBXO32/Atrogin-1TRIM63/MuRF1 |
| spellingShingle | Tubagus Bahtiar Rusbana Afifah Zahra Agista Wahyu Dwi Saputra Yusuke Ohsaki Kouichi Watanabe Ardy Ardiansyah Slamet Budijanto Takuya Koseki Hisashi Aso Michio Komai Hitoshi Shirakawa Supplementation with Fermented Rice Bran Attenuates Muscle Atrophy in a Diabetic Rat Model Nutrients fermented rice bran muscle atrophy diabetes mellitus streptozotocin FBXO32/Atrogin-1 TRIM63/MuRF1 |
| title | Supplementation with Fermented Rice Bran Attenuates Muscle Atrophy in a Diabetic Rat Model |
| title_full | Supplementation with Fermented Rice Bran Attenuates Muscle Atrophy in a Diabetic Rat Model |
| title_fullStr | Supplementation with Fermented Rice Bran Attenuates Muscle Atrophy in a Diabetic Rat Model |
| title_full_unstemmed | Supplementation with Fermented Rice Bran Attenuates Muscle Atrophy in a Diabetic Rat Model |
| title_short | Supplementation with Fermented Rice Bran Attenuates Muscle Atrophy in a Diabetic Rat Model |
| title_sort | supplementation with fermented rice bran attenuates muscle atrophy in a diabetic rat model |
| topic | fermented rice bran muscle atrophy diabetes mellitus streptozotocin FBXO32/Atrogin-1 TRIM63/MuRF1 |
| url | https://www.mdpi.com/2072-6643/12/8/2409 |
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