Gene expression of Caenorhabditis elegans neurons carries information on their synaptic connectivity.
The claim that genetic properties of neurons significantly influence their synaptic network structure is a common notion in neuroscience. The nematode Caenorhabditis elegans provides an exciting opportunity to approach this question in a large-scale quantitative manner. Its synaptic connectivity net...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-12-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC1676027?pdf=render |
| _version_ | 1828396526199635968 |
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| author | Alon Kaufman Gideon Dror Isaac Meilijson Eytan Ruppin |
| author_facet | Alon Kaufman Gideon Dror Isaac Meilijson Eytan Ruppin |
| author_sort | Alon Kaufman |
| collection | DOAJ |
| description | The claim that genetic properties of neurons significantly influence their synaptic network structure is a common notion in neuroscience. The nematode Caenorhabditis elegans provides an exciting opportunity to approach this question in a large-scale quantitative manner. Its synaptic connectivity network has been identified, and, combined with cellular studies, we currently have characteristic connectivity and gene expression signatures for most of its neurons. By using two complementary analysis assays we show that the expression signature of a neuron carries significant information about its synaptic connectivity signature, and identify a list of putative genes predicting neural connectivity. The current study rigorously quantifies the relation between gene expression and synaptic connectivity signatures in the C. elegans nervous system and identifies subsets of neurons where this relation is highly marked. The results presented and the genes identified provide a promising starting point for further, more detailed computational and experimental investigations. |
| first_indexed | 2024-12-10T08:31:34Z |
| format | Article |
| id | doaj.art-9b1513c771ed42e9b49d3ddc6da463f7 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-10T08:31:34Z |
| publishDate | 2006-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-9b1513c771ed42e9b49d3ddc6da463f72022-12-22T01:56:05ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582006-12-01212e16710.1371/journal.pcbi.0020167Gene expression of Caenorhabditis elegans neurons carries information on their synaptic connectivity.Alon KaufmanGideon DrorIsaac MeilijsonEytan RuppinThe claim that genetic properties of neurons significantly influence their synaptic network structure is a common notion in neuroscience. The nematode Caenorhabditis elegans provides an exciting opportunity to approach this question in a large-scale quantitative manner. Its synaptic connectivity network has been identified, and, combined with cellular studies, we currently have characteristic connectivity and gene expression signatures for most of its neurons. By using two complementary analysis assays we show that the expression signature of a neuron carries significant information about its synaptic connectivity signature, and identify a list of putative genes predicting neural connectivity. The current study rigorously quantifies the relation between gene expression and synaptic connectivity signatures in the C. elegans nervous system and identifies subsets of neurons where this relation is highly marked. The results presented and the genes identified provide a promising starting point for further, more detailed computational and experimental investigations.http://europepmc.org/articles/PMC1676027?pdf=render |
| spellingShingle | Alon Kaufman Gideon Dror Isaac Meilijson Eytan Ruppin Gene expression of Caenorhabditis elegans neurons carries information on their synaptic connectivity. PLoS Computational Biology |
| title | Gene expression of Caenorhabditis elegans neurons carries information on their synaptic connectivity. |
| title_full | Gene expression of Caenorhabditis elegans neurons carries information on their synaptic connectivity. |
| title_fullStr | Gene expression of Caenorhabditis elegans neurons carries information on their synaptic connectivity. |
| title_full_unstemmed | Gene expression of Caenorhabditis elegans neurons carries information on their synaptic connectivity. |
| title_short | Gene expression of Caenorhabditis elegans neurons carries information on their synaptic connectivity. |
| title_sort | gene expression of caenorhabditis elegans neurons carries information on their synaptic connectivity |
| url | http://europepmc.org/articles/PMC1676027?pdf=render |
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