Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies
Despite decades of research and successful improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. In recent years, it has become clear that PC stem cells (PCSCs) are the driving force in tumorigenesis, relapse, metastasis, and therapeutic resistance of PC. In this min...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.935715/full |
| _version_ | 1817976988403499008 |
|---|---|
| author | Isis Wolf Isis Wolf Christian Gratzke Christian Gratzke Philipp Wolf Philipp Wolf |
| author_facet | Isis Wolf Isis Wolf Christian Gratzke Christian Gratzke Philipp Wolf Philipp Wolf |
| author_sort | Isis Wolf |
| collection | DOAJ |
| description | Despite decades of research and successful improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. In recent years, it has become clear that PC stem cells (PCSCs) are the driving force in tumorigenesis, relapse, metastasis, and therapeutic resistance of PC. In this minireview, we discuss the impact of PCSCs in the clinical practice. Moreover, new therapeutic approaches to combat PCSCs are presented with the aim to achieve an improved outcome for patients with PC. |
| first_indexed | 2024-04-13T22:10:15Z |
| format | Article |
| id | doaj.art-9b15ab24df6341d097dbfce5775b1bff |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T22:10:15Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9b15ab24df6341d097dbfce5775b1bff2022-12-22T02:27:46ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-07-011210.3389/fonc.2022.935715935715Prostate Cancer Stem Cells: Clinical Aspects and Targeted TherapiesIsis Wolf0Isis Wolf1Christian Gratzke2Christian Gratzke3Philipp Wolf4Philipp Wolf5Department of Urology, Medical Center-University of Freiburg, Freiburg, GermanyFaculty of Medicine, University of Freiburg, Freiburg, GermanyDepartment of Urology, Medical Center-University of Freiburg, Freiburg, GermanyFaculty of Medicine, University of Freiburg, Freiburg, GermanyDepartment of Urology, Medical Center-University of Freiburg, Freiburg, GermanyFaculty of Medicine, University of Freiburg, Freiburg, GermanyDespite decades of research and successful improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. In recent years, it has become clear that PC stem cells (PCSCs) are the driving force in tumorigenesis, relapse, metastasis, and therapeutic resistance of PC. In this minireview, we discuss the impact of PCSCs in the clinical practice. Moreover, new therapeutic approaches to combat PCSCs are presented with the aim to achieve an improved outcome for patients with PC.https://www.frontiersin.org/articles/10.3389/fonc.2022.935715/fullprostate cancerprostate cancer stem cellsprostate cancer stem cell hypothesisprostate cancer stem cell antigensprostate cancer stem cell therapy |
| spellingShingle | Isis Wolf Isis Wolf Christian Gratzke Christian Gratzke Philipp Wolf Philipp Wolf Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies Frontiers in Oncology prostate cancer prostate cancer stem cells prostate cancer stem cell hypothesis prostate cancer stem cell antigens prostate cancer stem cell therapy |
| title | Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies |
| title_full | Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies |
| title_fullStr | Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies |
| title_full_unstemmed | Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies |
| title_short | Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies |
| title_sort | prostate cancer stem cells clinical aspects and targeted therapies |
| topic | prostate cancer prostate cancer stem cells prostate cancer stem cell hypothesis prostate cancer stem cell antigens prostate cancer stem cell therapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.935715/full |
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